Blood and Cystic Fluid From Patients Undergoing Surgery for Worrisome Pancreatic Cysts

Pilot Proof of Concept Study of miRNA and Protein Signatures in Exosomes From Blood and Cystic Fluid in Patients Undergoing Surgery for Worrisome Pancreatic Cysts

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07767227

Enrollment

Registered

2026-08-17

Start date

2025-02-03

Completion date

2028-03-01

Last updated

2026-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pancreatic Cyst

Brief summary

The goal of this study is to collect biospecimens (blood and cystic fluid) and data from participants who have a pancreatic cyst that requires surgical resection. The blood and fluid samples will be analyzed for research into DNA, RNA, and proteins.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Voluntarily agree to participate by giving written informed consent prior to any study-specific procedures. * Subject at least 18 years of age and able to provide consent. Subject is willing and able to comply with requirements of the protocol. * Radiologically documented cyst of the pancreas for which surgical removal is clinically indicated. * Patient will be undergoing a surgical resection of their pancreatic cystic neoplasm.

Exclusion criteria

* Patient who is pregnant at the time of study enrollment and sample collection. * Patient will not be undergoing clinically indicated surgery for a pancreatic cystic neoplasm. * Patient is unwilling or unable to provide informed consent or comply with study procedures.

Design outcomes

Primary

Measure	Time frame
Characterize the miRNA and protein signatures in exosomes derived from blood and cyst fluids in patients with worrisome cystic pancreatic tumors	At enrollment

Countries

United States

Contacts

CONTACTMichael Demeure, MD

clinicalresearch@hoag.org949-764-4577

PRINCIPAL_INVESTIGATORMichael Demeure, MD

Hoag Family Cancer Institute

Outcome results