Intact Cognitive Function, MCI, Mild Dementia
Conditions
Brief summary
The goal of this clinical study is to learn if an artificial intelligence (AI)-assisted lifestyle intervention program can help protect memory and thinking skills in adults aged 40 years and older who do not have severe cognitive impairment. It will also learn whether the program can help people maintain healthier lifestyle habits and whether it affects blood markers related to Alzheimer's disease. The main questions it aims to answer are: Can the AI-assisted program help participants improve their lifestyle, including diet, exercise, mental activities, social participation, sleep, smoking, alcohol use, and stress? Does a healthier lifestyle help maintain memory and thinking skills over 1 year? Are healthier lifestyle habits related to changes in blood markers such as p-tau217, which may be related to Alzheimer's disease? Does the effect differ for people who carry the APOE ε4 gene, a gene that may increase the risk of Alzheimer's disease? Researchers will compare participants with healthier lifestyles to those with less healthy lifestyles, to see whether healthier lifestyles are linked to better memory and thinking and different blood marker levels. Participants will: Join an online lifestyle intervention program for 1 year. Receive personalized advice about diet, exercise, mental activities, and social participation through an online platform, WeChat tools, an AI assistant, and online messages. Complete memory and thinking tests and lifestyle questionnaires at the start of the study, at 6 months, and at 12 months. Give blood samples at the start of the study and at 12 months for tests related to Alzheimer's disease. Have APOE gene testing at the start of the study.
Interventions
BEHAVIORALLifestyle Intervention
Healthy lifestyle guidance, including diet, cognitive activities, physical activity, social participation, smoking cessation, alcohol abstinence or moderation, sleep management, and stress management.
Sponsors
National Research Center for Rehabilitation Technical Aids
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
1. Chinese community-dwelling residents aged ≥ 40 years; 2. Cognitive function adequate to cooperate with testing and interventions; 3. No history of major neurological or psychiatric disorders; 4. Not on long-term use of medications known to affect cognitive function significantly ; 5. Possess the basic access and ability to use smartphones or the internet to receive online interventions; 6. Good compliance, with the expected ability to adhere to and complete a 1-year follow-up.
Exclusion criteria
1. Age \< 40 years; 2. Cognitive function inadequate to cooperate with testing and interventions; 3. History of major neurological disorders (e.g., stroke, Parkinson's disease, brain tumors, epilepsy) or severe psychiatric disorders (e.g., schizophrenia, severe depressive episodes); 4. Currently taking medications known to significantly affect cognitive function (e.g., anticholinergic drugs, certain psychotropic medications); 5. Presence of severe systemic or physical illnesses (e.g., advanced malignancy, severe heart, lung, liver, or kidney failure); 6. Lack of access to smartphones or the internet, rendering the participant unable to receive online interventions; 7. Any other conditions deemed by the investigator as inappropriate for participation in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive Function | Baseline to 6 months, and Baseline to 12 months | Assessed using comprehensive cognitive tests covering multiple domains (orientation, attention, naming, memory, digit span, visuospatial function, and processing speed) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| AD Biomarkers | Baseline to 12 months | Blood biomarker testing to assess Alzheimer's disease-related pathological changes (e.g., Change in Plasma p-tau217 Levels) |
Contacts
CONTACTXinxin Wang
Outcome results
None listed