Malignant Pleural Effusion, Tuberculous Pleural Effusion
Conditions
Keywords
Cancer ratio, Cancer ratio plus, Serum LDH, Pleural fluid ADA, Pleural fluid analysis
Brief summary
This prospective observational analytical study aims to assess the diagnostic value of Cancer Ratio and Cancer Ratio Plus in differentiating malignant pleural effusion from tuberculous pleural effusion. Adult patients with confirmed malignant or tuberculous pleural effusion will be recruited from the Chest Diseases Department, Sohag University Hospitals. Clinical, laboratory, and radiological data will be collected, and the diagnostic performance of both markers will be evaluated.
Interventions
DIAGNOSTIC_TESTCancer Ratio and Cancer Ratio Plus
Cancer Ratio and Cancer Ratio Plus will be calculated using serum LDH, pleural fluid ADA, and pleural fluid lymphocyte percentage to assess their diagnostic value in differentiating malignant pleural effusion from tuberculous pleural effusion. 1. Cancer Ratio CR =Serum LDH /pleural fluid ADA . 2. Cancer Ratio Plus = Serum LDH/(pleural fluid ADA × pleural fluid Lymphocyte fraction )
Sponsors
Sohag University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Adult patients (≥18 years) * Patients with Malignant or tuberculous pleural effusion * Availability of complete pleural fluid analysis including lymphocyte percentage ,pleural fluid ADA, and Serum LDH level
Exclusion criteria
* Patients with mixed etiology effusions (e.g., malignancy with infection) * Prior pleural interventions affecting fluid analysis * Incomplete clinical or laboratory data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic performance of Cancer Ratio and Cancer Ratio Plus in differentiating malignant from tuberculous pleural effusions | through study completion, an average of 1 year. | Diagnostic performance will be assessed by the area under the receiver operating characteristic curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and optimal cutoff values for differentiating malignant pleural effusion from tuberculous pleural effusion. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation of Cancer Ratio and Cancer Ratio Plus with clinical and radiological characteristics | through study completion , an average of 1 year . | Assessment of the association between Cancer Ratio and Cancer Ratio Plus values and the clinical and radiological characteristics of patients with malignant and tuberculous pleural effusions. |
Contacts
CONTACTDina MA Mohamed Ahmed, M.B.B.Ch.
CONTACTEnas K Ahmed, Lecturer
Outcome results
None listed