Exercise-induced Cartilage Turnover, Exercise-induced Joint Pain, Exercise-induced Joint Stiffness, Exercise-induced Muscle Soreness
Conditions
Keywords
intense exercise, NEM, curQ+, eggshell membrane, curcumin
Brief summary
Eggshell membrane and Curcumin supplementation prior to intense exercise may reduce inflammation, muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients affects recovery from intense exercise.
Detailed description
Eggshell membrane (EM) is derived from the inner fibrous layer of eggs that contain a number of proteins and Types I, V, and X collagen and sulfur containing amino acids (i.e., e.g., methionine, cysteine), glycosaminoglycans (e.g., hyaluronic acid, dermatan sulfate, chondroitin sulfate) that are found in synovium, cartilage, ligaments, and tendons of human joint tissue. Initial studies have shown that EM supplementation reduces inflammation and perception of pain while improving markers of joint health in individuals with osteoarthritis. Curcumin (Curcuma longa) is a member of the ginger family (Zingiberaceae) that contains polyphenols that have anti-inflammatory properties. Studies show that curcumin (Curc) can reduce inflammation related to osteoarthritis, exercise, concussion and traumatic brain injury. Theoretically, EM and Curc supplementation prior to intense exercise may reduce inflammation, perceptions of muscle and joint pain, and promote recovery. This proof-of-concept study will examine how ingestion of specially formulated versions of these nutrients (NEM® brand eggshell membrane and curQ+® brand highly absorbable curcumin) separately and in combination affects recovery from intense exercise in recreationally active men.
Interventions
DIETARY_SUPPLEMENTNEM® brand eggshell membrane powder
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule.
DIETARY_SUPPLEMENTcurQ+® brand highly absorbable curcumin
2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
DIETARY_SUPPLEMENTEM Placebo
500 mg/day of psyllium husk fiber powder in a single #0 capsule.
DIETARY_SUPPLEMENTCurc Placebo
2,860 mg/day of coconut oil/polysorbate blend in a single 10 Oval softgel.
DIETARY_SUPPLEMENTNEM® plus curQ+® combination
500 mg/day of NEM® brand eggshell membrane powder in a single #0 capsule PLUS 2,860 mg/day of curQ+® brand highly absorbable curcumin in a single 10 Oval softgel.
Sponsors
ESM Technologies, LLC
Exercise & Sport Nutrition Lab, Texas A&M University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Intervention model description
Single-Dummy, Placebo-controlled, Parallel-Group
Eligibility
Sex/Gender
MALE
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18 to 40 at the time of consent. * Healthy and recreationally active. * Ability to comply with study procedures. * Agree to refrain from alcohol intake and use of non-steroidal anti-inflammatory (NSAIDS), aspirin, and other over-the-counter pain medications for 48 hours prior to and after completion of each testing session.
Exclusion criteria
* No recent history of exercise training * An orthopedic limitation that would prevent the ability to perform the exercise intervention. * Participants who currently smoke cigarettes. * Known allergies to eggs, sulfur, or curcumin.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS Muscle Soreness Rating | 2 weeks | Changes in Visual Analog Scale (VAS) ratings of muscle soreness (rated from zero to 100 mm) from baseline following intense exercise. The higher the rating, the more muscle soreness so negative changes in VAS would equate to improvement. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammation Biomarkers | 2 weeks | Changes in markers of inflammation (TNFα, interleukin (IL) cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10) from baseline following intense exercise. |
| Muscle Damage | 2 weeks | Changes in markers of muscle enzyme efflux/damage (CK, LDH) from baseline following intense exercise. |
| Exercise Performance | 2 weeks | Changes in exercise performance (strength, muscular endurance, peak aerobic capacity) from baseline following intense exercise. |
| Urinary CTX-II | 2 weeks | Changes in urinary CTX-II biomarker from baseline following intense exercise. |
Countries
United States
Contacts
CONTACTRichard B. Kreider, Ph.D.
CONTACTChristopher Rasmussen, M.S.
PRINCIPAL_INVESTIGATORRichard B. Kreider, Ph.D.
Exercise & Sport Nutrition Lab, Texas A&M University
STUDY_DIRECTORKevin J. Ruff, Ph.D.
ESM Technologies, LLC
Outcome results
None listed