Cognitive Function, Cognitive Performance, Mood
Conditions
Brief summary
This study evaluates the effects of two liquid dietary supplements, BrainJuice Peach Mango (test product one) and BrainJuice ACTIVE Pomegranate Acai (test product two), on cognitive function, cognitive performance, and mood in healthy adults aged 18-57 who report concerns in these areas. The trial is a six-week, single-arm, open-label, virtual study enrolling 30 participants. Participants will consume test product one (2.5 oz once daily) during Weeks 1 and 2, undergo a washout period during Weeks 3 and 4, and then consume test product two (2.5 oz once daily) during Weeks 5 and 6. Cognitive function will be assessed via standardized computerized cognitive assessments at Baseline, Week 2, Week 4, and Week 6, while perceptions of cognitive function, cognitive performance, and mood will be captured through self-reported questionnaires at Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6.
Interventions
DIETARY_SUPPLEMENTBrainJuice Supplement
All participants consume BrainJuice Peach Mango (test product one, 2.5 oz once daily) during Weeks 1 and 2, followed by a washout period during Weeks 3 and 4 with no test product, followed by BrainJuice ACTIVE Pomegranate Acai (test product two, 2.5 oz once daily) during Weeks 5 and 6. There is no comparator or placebo arm.
Sponsors
BrainJuice
Citruslabs
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 57 Years
Healthy volunteers
Yes
Inclusion criteria
* Be male or female * Be aged 18-57 * Anyone experiencing concerns regarding all of the following over the past four weeks: Cognitive Function, Cognitive Performance, and Mood * Anyone who is generally healthy - does not live with any uncontrolled chronic disease * If taking oral over-the-counter supplements or herbal remedies targeted at cognitive function, cognitive performance, or mood, has been consistently taking these for at least 3 months prior to starting the study, and is willing to maintain this routine for the study duration * Anyone who is a regular caffeine consumer without a history of caffeine sensitivity or intolerance * Willing to maintain the same diet and exercise regimen consistently throughout the study duration * Willing to limit caffeine consumption to one additional serving of caffeine outside of the test product i.e. one cup of brewed coffee (\~100 mg), one matcha (\~60 mg), two shots of espresso (\~120 mg), or one cup of caffeinated tea (\~50 mg) * Resides in the United States * Has access to a computer or tablet device
Exclusion criteria
* Anyone with pre-existing chronic conditions, including but not limited to oncological, uncontrolled hypertension (high blood pressure) or hypotension (low blood pressure), heart disease, diabetes and psychiatric disorders * History of neurodegenerative disease (e.g., Alzheimer's, Parkinson's), history of traumatic brain injury (including concussions), stroke, epilepsy, or uncontrolled migraine * History of mood disorders, such as depression, bipolar disorder, or seasonal affective disorder * History of sleep disorders, such as insomnia, narcolepsy, or sleep apnea * Anyone with a job that involves shift work that may be overnight or night hours * Planning on introducing any products or any new forms of prescription medication or supplements that target cognitive function, cognitive performance, or mood, for the study duration * Anyone with any allergies or sensitivities to any of the study product ingredients * Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period) * Anyone unwilling to follow the study protocol * Anyone with a history of substance abuse * Anyone who is currently a smoker or has been a smoker in the past 3 months * Currently partaking in another research study or will be partaking in any other research study at any point during this study's duration
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Cognitive Assessment Score (Polygons) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Polygons processing test score from Baseline, measured via computerized cognitive assessment |
| Change in Cognitive Assessment Score (Double Trouble) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Double Trouble selective attention and processing speed test score from Baseline, measured via computerized cognitive assessment |
| Change in Cognitive Assessment Score (Feature Match) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Feature Match focus and processing test score from Baseline, measured via computerized cognitive assessment |
| Change in Cognitive Assessment Score (Paired Associates) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Paired Associates memory task score from Baseline, measured via computerized cognitive assessment |
| Change in Cognitive Assessment Score (Digit Span) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Digit Span short-term memory and attention test score from Baseline, measured via computerized cognitive assessment |
| Change in Cognitive Assessment Score (Spatial Planning) | Baseline, Week 2, Week 4, and Week 6 | Mean change in Spatial Planning executive function test score from Baseline, measured via computerized cognitive assessment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Self-Reported Focus | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived focus from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Attention | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived attention from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Concentration | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived concentration from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Productivity | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived productivity from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Alertness | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived alertness from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Mental Clarity | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived mental clarity from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Mood | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived mood from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Mental Fatigue | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived mental fatigue from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Motivation | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived motivation from Baseline, assessed via self-reported questionnaire |
| Change in Self-Reported Organization | Baseline, Week 1, Week 2, Week 4, Week 5, and Week 6 | Mean change in perceived organization from Baseline, assessed via self-reported questionnaire |
Countries
United States
Outcome results
None listed