Asthma (Diagnosis)
Conditions
Keywords
Exercise-induced wheezing, Dyspnea
Brief summary
Exertional dyspnea has a significant impact on a child's daily life. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB). But the test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children.
Detailed description
Exertional dyspnea is a frequent reason for consultation in pediatric pulmonology. The perception of dyspnea varies from one child to another, with some children over- or under- perceiving its intensity. Dyspnea has a significant impact on a child's daily life and quality of life and, in pediatrics, always raises the suspicion of exercise-induced asthma. Current guidelines recommend performing an exercise challenge test to confirm or rule out exercise-induced bronchoconstriction (EIB) if it is suspected. However, this test is not widely available. The objective of this research is to identify the clinical and respiratory functional factors predictive of a positive exercise challenge test in children. The potential benefit of this study is to better identify individuals who would benefit from undergoing an exercise challenge test.
Interventions
None listed
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
5 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
* Children aged 5 to 18 years who performed an exercise challenge test during the years 2024 and 2025
Exclusion criteria
* Children with doctor-diagnosed asthma
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of wheezing at exercise | The test duration (3 hours) | Presence of reported exercise-induced wheezing, as documented in the subject's electronic medical record (yes/no; binary variable). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Presence of reported dyspnea at exercise | The test duration 3 hours | Presence of reported exercise-induced dyspnea, as documented in the subject's electronic medical record (yes/no; binary variable). |
| Presence of reported cough at exercise | The test duration 3 hours | Presence of reported exercise-induced cough, as documented in the subject's electronic medical record (yes/no; binary variable). |
| Presence of reported chest tightness at exercise | The test duration 3 hours | Presence of reported exercise-induced chest tightness, as documented in the subject's electronic medical record (yes/no; binary variable). |
| Functional parameters - FEV1 z-score at baseline | The test duration 3 hours | Spirometric parameters measured before exercise testing - FEV1 z-score (forced expiratory volume in 1 sec) from spirometry performed before exercise testing and documented in the electronic folder of the patient |
| Reported atopy | The test duration 3 hours | Presence of asthma or atopy history, as documented in the subject's electronic medical record (yes/no; binary variable). |
| Reported clinical history | The test duration 3 hours | Reported early respiratory history (≥ 3 wheezing episodes before the age of 3 years; at least one episode of pneumonia or atelectasis), from the clinical history recorded in the electronic folder of the patients (yes/no, binary variable) |
| Functional parameters - FEV1/FVC z-score at baseline | The test duration 3 hours | Spirometric parameters measured before exercise testing - FEV1/FVC z-score (FVC = forced vital capacity) from spirometry performed before exercise testing and documented in the electronic folder of the patient |
Countries
France
Outcome results
None listed