Bone Density, Bone Width, Radiographic Evaluation, Socket Preservation, Thymoquinone, Tooth Extraction
Conditions
Brief summary
This study aims to evaluate the clinical and radiographic effects of 0.2% Thymoquinone gel on bone density, bone width, and socket preservation after tooth extraction.
Detailed description
Tooth extraction triggers a cascade of biological events which lead to significant remodeling of the alveolar ridge, frequently resulting in reductions in both bone width and height. The concept of alveolar ridge preservation (ARP) has developed to address the bone resorption that follows extraction. ARP aims to maintain ridge dimensions and reduce the need for further augmentation before implant placement. Among these, the small-molecule Thymoquinone (TQ), derived from Nigella sativa, has demonstrated significant osteogenic, anti-inflammatory, and antioxidant effects in preclinical studies.
Interventions
DRUGGel foam
Patients will receive gel foam only.
DRUGThymoquinone gel + gel foam
Patients will receive 0.2% thymoquinone gel + gel foam.
DRUGNano-formulated 0.2% thymoquinone gel + gel foam
Patients will receive nano-formulated 0.2% thymoquinone gel + gel foam.
Sponsors
Kafrelsheikh University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Age: 18-50 years. * Both sexes. * Patients requiring extraction of upper posterior teeth will be recruited.
Exclusion criteria
* Healthy subjects with intact sockets after extraction. * Normal mouth opening and good oral hygiene. * No systemic conditions affecting bone healing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in alveolar bone density after tooth extraction | 3 months after tooth extraction | Alveolar bone density will be assessed radiographically using cone-beam computed tomography (CBCT). The change in bone density from baseline to the specified postoperative assessment will be compared. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in alveolar bone width after tooth extraction | 3 months after tooth extraction | Alveolar bone width will be assessed radiographically using cone-beam computed tomography (CBCT). The change in alveolar ridge width from baseline to the postoperative assessment will be measured. |
| Change in alveolar ridge dimension after tooth extraction | 3 months after tooth extraction | Alveolar ridge dimensions will be assessed radiographically using cone-beam computed tomography (CBCT). Changes in the dimensions of the alveolar ridge following tooth extraction will be measured and compared. |
Countries
Egypt
Contacts
CONTACTMuataz A Karimeh, Bachelor
Outcome results
None listed