Intracranial Stenosis, Intracranial Venous Pressures, Intracranial Venous Sinus Stenosis, Stent Implantation, Venous Sinus Stenosis
Conditions
Keywords
Photon-counting CT, Intracranial venous sinus stent, Ultra-high-resolution CT, CT angiography
Brief summary
This prospective observational study aims to evaluate the effectiveness of ultra-high-resolution photon-counting CT angiography (UHR PCD-CTA) for noninvasive assessment of intracranial venous sinus stents. The study will compare image quality, stent visualization, metal-related artifacts, and diagnostic accuracy between PCD-CTA and conventional energy-integrating detector CT angiography (EID-CTA).
Detailed description
Intracranial venous sinus stenting has become an important treatment option for patients with symptomatic venous sinus stenosis, particularly those with idiopathic intracranial hypertension. Accurate imaging follow-up after stent placement is essential for evaluating stent patency, recurrent stenosis, and potential complications such as in-stent thrombosis or occlusion. Conventional CT angiography (CTA) is commonly used for noninvasive follow-up after venous sinus stent implantation; however, accurate assessment of stented venous sinuses remains challenging due to metal-related artifacts. Blooming artifact caused by the high attenuation of metallic stent material may result in overestimation of stent thickness and obscuration of the stent lumen. In addition, beam-hardening artifacts from the stent and adjacent skull structures may further degrade image quality and reduce diagnostic confidence, potentially limiting the ability of CTA to detect clinically significant restenosis or thrombotic complications.
Interventions
None listed
Sponsors
Xin Lou
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Inclusion criteria
* Adults aged ≥18 years. * History of intracranial venous sinus stent implantation. * Undergoing follow-up contrast-enhanced CT angiography after stent -placement. * Available clinical and imaging data.
Exclusion criteria
* Severe motion artifacts affecting image interpretation. * Contraindication to iodinated contrast media. * Severe renal impairment preventing contrast-enhanced CT examination. * Incomplete imaging data. * Other conditions preventing reliable assessment of the venous sinus stent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Agreement between UHR PCD-CTA and DSA for intracranial venous sinus stent patency | 1-4 years | Agreement between ultra-high-resolution photon-counting detector CT angiography (UHR PCD-CTA) and digital subtraction angiography (DSA) for the assessment of intracranial venous sinus stent patency will be quantified using Cohen's kappa (κ) coefficient. Stent patency will be classified according to the predefined diagnostic criteria, with DSA serving as the reference standard. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Signal-to-noise ratio on UHR PCD-CTA | 1-4years | Signal-to-noise ratio (SNR) will be calculated using CT attenuation and image noise measurements obtained from predefined regions of interest on UHR PCD-CTA images. |
Countries
China
Contacts
CONTACTJinhao Lyu, MD
CONTACTJinying He
STUDY_CHAIRXin Lou
Chinese PLA General Hospital
Outcome results
None listed