Photon-Counting CT Versus Conventional CT for Carotid Plaque Assessment in Patients With Carotid Artery Stenosis

Prospective Comparison of Photon-Counting Detector CT and Conventional Energy-Integrating Detector CT for Carotid Atherosclerotic Plaque Assessment in Patients With Carotid Artery Stenosis

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07762664

Enrollment

100

Registered

2026-08-13

Start date

2026-01-07

Completion date

2029-01-07

Last updated

2026-08-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Artery Stenosis, Carotid Atherosclerosis, Carotid Atherosclerotic Plaque

Keywords

Photon-Counting CT, Carotid Artery Stenosis, Plaque Characterization, Carotid Plaque

Brief summary

Detailed description

This prospective observational study aims to compare photon-counting detector computed tomography angiography (PCD-CTA) with conventional energy-integrating detector computed tomography angiography (EID-CTA) for the assessment of carotid atherosclerotic plaques in patients with carotid artery stenosis. The study will evaluate differences between the two CT techniques in the visualization and quantitative characterization of carotid plaques, including plaque morphology, plaque burden, plaque components, calcification-related artifacts, and degree of carotid artery stenosis. Objective and subjective image quality will also be compared. The study is intended to determine whether the improved spatial resolution and spectral imaging capabilities of photon-counting CT provide advantages over conventional CT for the characterization of carotid atherosclerotic disease.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

10 Years to 90 Years

Inclusion criteria

* Age 18 years or older. * Patients with carotid atherosclerotic plaque or carotid artery stenosis. * Patients scheduled to undergo carotid artery stenting. * Patients undergoing preprocedural carotid CTA examination. * Ability to provide written informed consent.

Exclusion criteria

* Known allergy to iodinated contrast material. * Severe renal insufficiency or other contraindications to contrast-enhanced CT. * Pregnancy or suspected pregnancy. * Severe motion or other artifacts resulting in nondiagnostic image quality. * Incomplete clinical or imaging data.

Design outcomes

Primary

Measure	Time frame	Description
Carotid Plaque Visualization and Characterization on PCD-CTA Compared With Conventional EID-CTA	1-4 years	Carotid atherosclerotic plaques will be independently evaluated on photon-counting detector CTA and conventional energy-integrating detector CTA.

Secondary

Measure	Time frame	Description
Contrast-to-noise ratio on PCD-CTA compared with conventional EID-CTA	1-4years	Contrast-to-noise ratio (CNR) will be quantitatively calculated from measurements obtained on PCD-CTA and conventional EID-CTA using a predefined measurement method. CNR values will be compared between the two CT techniques.

Countries

China

Contacts

CONTACTJinhao Lyu, MD

330322990@qq.com+8615903562929

CONTACTJinying He

1527012389@qq.com

STUDY_CHAIRXin Lou

Chinese PLA General Hospital

Outcome results