Chronic Obstructive Pulmonary Disease
Conditions
Keywords
Chronic obstructive pulmonary disease, Dynamic Chest Radiography
Brief summary
To evaluate the utility of DCR-derived parameters for identifying dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of disease progression in COPD.
Detailed description
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. Approximately 100 million people in China have COPD, yet the early diagnosis rate remains below 13%. This multicenter retrospective study will collect previously acquired dynamic chest radiography (DCR) images, pulmonary function test results, chest computed tomography images, symptom scores, clinical data, and follow-up outcomes from participating centers. A standardized multicenter retrospective DCR-COPD database will be established to systematically evaluate the utility of DCR-derived parameters for characterizing dynamic functional imaging phenotypes, assessing disease severity, and predicting the risk of COPD progression. The study will also provide a foundation for model development and subsequent prospective multicenter validation.
Interventions
None listed
Sponsors
Nanfang Hospital, Southern Medical University
The First Affiliated Hospital of Guangzhou Medical University
Qingyuan People's Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
30 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
1. Aged 30-85 years. 2. Male or female. 3. Patients who underwent pulmonary function testing and dynamic chest radiography at the hospital.
Exclusion criteria
1. Incomplete medical records. 2. Considered unsuitable for inclusion in the study at the investigator's discretion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Exacerbation/respiratory history and event | At Baseline | Measurement of disease control and burden |
| FEV1 % | At Baseline | Measurement of lung function |
| FEV1 /FVC | At Baseline | Measurement of lung function |
| Emphysema | At Baseline | Measurement of chest CT |
| diaphragm movement | At Baseline | Measurement of Dynamic chest radiograph |
| lung field area | At Baseline | Measurement of Dynamic chest radiograph |
| lung field area change rate | At Baseline | Measurement of Dynamic chest radiograph |
| CAT | At Baseline | Measurement of questionnaires |
| SGRQ | At Baseline | Measurement of questionnaires |
| mMRC | At Baseline | Measurement of questionnaires |
| Smoking history and status | At Baseline | Risk factors of COPD development or lung function decline |
Countries
China
Contacts
CONTACTLaiyu Liu, Professor
CONTACTDong Yu
STUDY_CHAIRLaiyu Liu, professor
Nanfang Hospital, Southern Medical University
Outcome results
None listed