Hemoglobin Trends as a Predictor of Outcomes in Critically Ill Patients (The TRENT-ICU Study)

The TRENT-ICU Study (Transfusion Threshold Based on Hemoglobin Trends): Hemoglobin Drop Rate as a Predictor of Adverse Clinical Outcomes in Critically Ill Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07761832

Enrollment

128

Registered

2026-08-12

Start date

2026-07-31

Completion date

2026-07-31

Last updated

2026-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anemia, Critical Illness

Keywords

critical care, Hemoglobins, Blood Transfusion, Prognosis, Intensive Care Units

Brief summary

The goal of this observational study is to evaluate if early absolute hemoglobin decline (during the first 24 hours of admission) can predict prolonged intensive care unit stay (8 days or more) and in-hospital mortality in critically ill adult patients. The main questions it aims to answer are: Does absolute hemoglobin decline during the first 24 hours of admission independently predict prolonged intensive care unit stay in critically ill adult patients? Does absolute hemoglobin decline during the first 24 hours of admission independently predict in-hospital mortality in critically ill adult patients? Participants will: Have their routine clinical and laboratory data reviewed retrospectively from their electronic health records (including baseline hemoglobin and a second hemoglobin determination approximately 24 hours after admission). No additional interventions or extra blood draws will be performed beyond routine clinical care.

Interventions

OTHEREarly Absolute Hemoglobin Decline

Measurement of the absolute difference in hemoglobin concentration (g/dL) between baseline ICU admission and approximately 24 hours post-admission. Data was collected retrospectively from electronic health records.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients (aged 18 years or older) admitted to the Intensive Care Unit (ICU) between January 2024 and January 2026. * ICU length of stay greater than 48 hours. * At least two hemoglobin determinations obtained with an interval of approximately 24 hours apart during routine medical care.

Exclusion criteria

* Massive bleeding upon ICU admission. * Massive transfusion protocol activation. * Pregnancy. * Hemoglobinopathies. * Active hemolytic anemia. * Medical records with insufficient information for analysis.

Design outcomes

Primary

Measure	Time frame	Description
Prolonged Intensive Care Unit Stay	From ICU admission up to 28 days	Incidence of prolonged intensive care unit (ICU) length of stay, defined a priori as an ICU stay equal to or greater than 8 days.

Secondary

Measure	Time frame	Description
In-Hospital Mortality	From ICU admission up to 30 days	Incidence of all-cause mortality recorded at hospital discharge.

Countries

Mexico

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 13, 2026