Caesarian Section
Conditions
Brief summary
The goal of this clinical trial is to learn whether giving a single dose of intravenous dexamethasone before spinal anesthesia can help prevent low blood pressure (spinal hypotension) in pregnant women undergoing elective cesarean section. Low blood pressure after spinal anesthesia is common and may cause nausea, vomiting, dizziness, and reduced blood flow to the baby. If dexamethasone works, it may help maintain stable blood pressure during surgery, reduce the need for medicines used to treat low blood pressure, and improve the safety and comfort of both the mother and baby. The main questions it aims to answer are: * Does preoperative intravenous dexamethasone reduce the occurrence of spinal hypotension after spinal anesthesia? * Does dexamethasone reduce the amount of vasopressor medicine needed to treat low blood pressure during surgery? Researchers will compare 8 mg intravenous dexamethasone with normal saline (placebo) to determine whether dexamethasone is more effective in preventing spinal hypotension during elective cesarean section. Participants will: * Receive either intravenous dexamethasone or a placebo before spinal anesthesia. * Undergo elective cesarean section under spinal anesthesia. * Have their blood pressure monitored during surgery. * Receive standard treatment if their blood pressure becomes too low. * Have their blood pressure measurements and the need for blood pressure-raising medicines recorded to compare the effects of the two treatments.
Interventions
DRUGDexamethasone
Dexamethasone
Sponsors
Liaquat National Hospital & Medical College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Pregnant females Consenting No contraindications
Exclusion criteria
* Non consenting
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Spinal hypotension | From spinal anesthesia until delivery of the baby (approximately 20 minutes) at 5 minutes interval for a period of 6 months. | The incidence of spinal hypotension, defined as a decrease in systolic blood pressure (SBP) greater than 20% of the baseline value or an absolute SBP \<90 mmHg after spinal anesthesia, will be compared between the dexamethasone and placebo groups. Blood pressure will be measured every 5 minutes until delivery of the baby. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vasopressor Requirement | From spinal anesthesia until delivery of the baby (approximately 20 minutes ) at 5 minutes interval for a period of 6 months | Total dose and frequency of vasopressor administration required to treat spinal hypotension following spinal anesthesia will be compared between the dexamethasone and placebo groups. |
Countries
Pakistan
Outcome results
None listed