Chronic Lymphocytic Leukemia (CLL), Hairy Cell Leukemia (HCL), Splenic Marginal Zone Lymphoma
Conditions
Keywords
B-cell malignancies, 3D models
Brief summary
Adult patients with chronic lymphocytic leukemia (CLL), splenic marginal-zone lymphoma (SMZL) and hairy cell leukemia (HCL) followed at participating clinical sites will be enrolled and undergo sampling of additional amount of blood during the blood draws performed as part of standard clinical care. The project aims to develop and validate innovative patient-derived 3D bioprinted models that faithfully reproduce the key microenvironments of lymphoid tissues, enabling a more physiologically relevant study of mature B-cell malignancies.
Interventions
None listed
Sponsors
IRCCS San Raffaele
Ministry of Health, Italy
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age ≥18 years * Diagnosis of CLL, SMZL or HCL * Participant is willing and able to autonomously give informed consent for participation in the study.
Exclusion criteria
\- Participant is unable or unwilling to provide informed consent for participation in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To generate 3D culture models from patients with CLL, SMZL, HCL | 36 months | ≥50% 3D culture models generated from patients with CLL, SMZL and HCL, defined as cell viability \>80% per sample in standard condition |
Countries
Italy
Contacts
CONTACTCristina Scielzo, PhD
CONTACTLydia Scarfò, MD
Outcome results
None listed