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The First-Night Effect and Sex Differences in Strength and Muscular Endurance Performance

The First-Night Effect: Sex Differences in the Impact of Unfamiliar Sleeping Environment on Strength and Muscular Endurance Performance in Resistance-trained Participants

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07758166
Enrollment
32
Registered
2026-08-11
Start date
2024-02-07
Completion date
2026-05-03
Last updated
2026-08-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sleep

Brief summary

Introduction: The first-night effect, characterized by disturbed sleep in an unfamiliar environment, may impair next-day physical performance. However, whether this response differs between men and women remains unclear. This study investigated sex differences in the effects of sleeping in an unfamiliar environment on strength and muscular endurance in resistance-trained individuals. Methods: Thirty-two resistance-trained participants (16 women, 16 men; 23 ± 4 years) completed a randomized, counterbalanced crossover study involving two conditions: sleeping for 8 h at home or in the laboratory. The following morning, participants performed bench press and back squat strength tests across 25-90%1RM, followed by muscular endurance tests to failure at 65%1RM.

Interventions

BEHAVIORALFirst-Night Effect at the laboratory

Participants sleep 8h at the laboratory

BEHAVIORALfirst-night effect (at home)

Participants sleep 8h at home

Sponsors

University of Alcala
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
SINGLE (Investigator)

Masking description

Investigador and Statistician were blinded

Eligibility

Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes

Inclusion criteria

* Age between 18 and 35 years.• Body Mass Index (BMI) \< 25 kg/m². * Resistance-trained individuals (more than 2 years of structured training). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from exercising. * Participants must be able to perform the tests described in the following section.

Exclusion criteria

* History of neuromuscular diseases, heart disease, or conditions that may affect liver or muscle metabolism. * Use of drugs, stimulants, or sports supplements that could interfere with the dietary supplement used in the study. * Sedentary habits (less than 150 minutes/week of moderate exercise).• Having undergone prolonged periods of physical inactivity in the 6 months prior to the study. * Engaging in strenuous exercise within 48 hours prior to the tests.• Failure to replicate the same food intake on both experimental days. * Consumption of caffeine or any other stimulant the day before the tests.

Design outcomes

Primary

MeasureTime frameDescription
Mean concentric velocity at 25%, 50%, 75%, and 90% 1RM (m/s)Through study completion, an average of 3 weeksMean velocity at different %1RM (25%, 50%, 75%, 90%)
Number of repetitions performed to task failure during the bench press and back squat exercises at 65% 1RM.Through study completion, an average of 3 weeksIn bench press and back squat exercises
Bar velocity displacement (mean velocity, m/s) performed in 1 set at 65%1RM until task failureThrough study completion, an average of 3 weeksIn bench press and back squat exercises
Maximal force during handgrip and isometric mid-thigh pull tests (N)Through study completion, an average of 3 weekN generated
Vertical Jump test (CMJ)Through study completion, an average of 3 weekcm of Height and W/kg generate during a CMJ

Secondary

MeasureTime frameDescription
Mood state (tension, depression, anger, vigor, fatigue and confusion)Through study completion, an average of 3 weeksParticipants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question;How do you feel at this moment?; to assess six scales: tension, depression, anger, vigor, fatigue and confusion.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 1, 2026