Comparison of Two Phacoemulsification Systems in Cataract Surgery (UNITY VCS vs. Centurion)

Comparison of Ultrasound Efficiency and Early Postoperative Outcomes of Two Phacoemulsification Systems (UNITY VCS 4D Phaco and Centurion With Active Sentry Probe): A Randomized Contralateral Eye Study

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07756385

Acronym

COMPASS

Enrollment

Registered

2026-08-10

Start date

2026-08-06

Completion date

2026-10-29

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cataract Surgery

Keywords

Phacoemulsification, UNITY VCS System 4D Phaco, Centurion Vision System with Active Sentry Handpiece, Contralateral eye study

Brief summary

This prospective, randomized, contralateral (crossover) study compares the ultrasound efficiency and early postoperative outcomes (Day 1 and Day 7) of two phacoemulsification platforms - the UNITY® VCS system with 4D Phaco and the Centurion® Vision System with ACTIVE SENTRY® Handpiece - used in the two eyes of the same patient undergoing cataract surgery.

Detailed description

Adult patients scheduled for uncomplicated phacoemulsification with comparable cataract density between eyes (within one LOCS III grade) will have one eye randomized to the UNITY VCS system and the contralateral eye to the Centurion Vision System, with the same surgeon and using the same low IOP fluidics parameters. The contralateral eye surgery will be performed two weeks after the first eye surgery. The study will evaluate ultrasound efficiency using machine-recorded parameters, best-corrected visual acuity (BCVA), and central corneal thickness (CCT) on postoperative Days 1 and 7.

Interventions

DEVICEUNITY VCS SYSTEM ®

4D PHACO PROBE

DEVICECENTURION VISION SYSTEM ®

ACTIVE SENTRY PROBE

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adult patients scheduled for uncomplicated phacoemulsification with comparable cataract density between eyes (within one LOCS III grade)

Exclusion criteria

* Prior corneal or intraocular surgery * Significant corneal pathology * Significant asymmetry between eyes in: cataract density, astigmatism, or axial length

Design outcomes

Primary

Measure	Time frame
Ultrasound efficiency evaluated through Cumulative Dissipated Energy (CDE) required to remove the cataract	Intraoperative

Secondary

Measure	Time frame
Ultrasound efficiency evaluated through Ultrasound (U/S) Total Time	Intraoperative
Ultrasound efficiency evaluated through Total Aspiration Time	Intraoperative
Ultrasound efficiency evaluated through Estimated Fluid Aspirated	Intraoperative
Ultrasound efficiency evaluated through Total Case Time	Intraoperative
Best-corrected visual acuity (BCVA)	Postoperative Day 1 and Day 7
Central corneal thickness (CCT)	Postoperative Day 1 and Day 7

Countries

Croatia

Contacts

CONTACTProf. Biljana Kuzmanović Elabjer, M.D., Ph.D.

belabjer@kbsd.hr+385912209555

CONTACTIva Ćubela, M.D.

icubela@kbsd.hr+385912223220

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 11, 2026