Cardiac Arrest (CA)
Conditions
Keywords
cardiac arrest, head up cpr, continuous adrenalin infusion, mechanical thorax compression, ITD, arterial line, diastolic blood pressure, ROSC, OHCA
Brief summary
The goal of this controlled single centre RCT is to compare frequency rates concerning return of spontaneous circulation (ROSC) in prehospital cardiac arrest. Two different algorithms (control-and interventiongroup) of advanced cardiac life support will be used to treat patients. In patients over 18 years suffering from cardiac arrest. The main question aims to answer if the frequency of ROSC differs between the groups receiving either the new Advanced Life Support (ALS) algorithm, or standard treatment. Researchers will compare the new algorithm to the standard care algorithm to see if there is a difference . Participants will be randomized to treatment on scene. The controlgroup will receive ALS standard treatment as performed in local protocols. The intervention group will receive a modified treatment including: * thorax compression via mechanical device (LUCAS 3) * head up Cardiopulmonary Resuscitation (cpr) * use of an impendance threshold device (ITD) module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation
Interventions
PROCEDUREaCPR algorithm
* thorax compression via mechanical device (LUCAS 3) * head up cpr * use of an ITD module * arterial line placement * continuous epinephrin infusion via infusion pump * double sequence defibrillation
PROCEDUREERC ALS 2025
Placement of an IV line, placement of a supraglottic airway device or endotracheal intubation. Optional use of an intraosseus acces
Sponsors
Johannes Kepler University of Linz
Red Cross Upper Austria
Kepler University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age\> 18 years * time of resuscitation \<21 minutes when enrollement starts
Exclusion criteria
* obvious pregnancy * contraindications for the use of Lucas 3 * time of resuscitation \>21 minutes and etCO2 \<15 mmHg upon arrival of the emergency physician on scene * Exclusion from the emergency physician from study due to futility.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ROSC | one minute | frequency of ROSC in the study cohort |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to ROSC | Periprocedural: from enrollement to ROSC or Termination of Resuscitation (TOR) | comparison between the groups if ROSC can be achieved faster in one group |
| CO2 | Periprocedural: from enrollement to ROSC orTOR | Measurement of CO2 differences between study arms |
| descriptive data | Periprocedural: during study intervention | analyzing vital parameters measured |
Countries
Austria
Contacts
PRINCIPAL_INVESTIGATORJens Meier, Univ. Prof.
Kepler University Hospital / Johannes Kepler University
Outcome results
None listed