Healthy Adult Volunteers, Musculoskeletal Health
Conditions
Keywords
Yijinjing, Healthy Adult Volunteers, Musculoskeletal Health
Brief summary
Observation of the effects of Yi Jin Jing on the muscles and bones of adults
Interventions
BEHAVIORALYijinjing
Yijinjing
Sponsors
Beijing Hospital of Traditional Chinese Medicine
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Age 18-90 years inclusive; * Generally healthy, no acute or chronic diseases affecting major organ functions; * No cognitive impairment, able to understand and comply with study procedures; * Willing and able to provide written informed consent; * No pregnancy or lactation (for females); * No recent (within 3 months) major surgery, hospitalization, or significant weight change (\>5% body weight).
Exclusion criteria
* Presence of acute or unstable chronic diseases (e.g., uncontrolled hypertension, diabetes, heart failure, or malignancy); * Severe cognitive impairment, psychiatric disorders, or inability to follow study instructions; * Recent (≤3 months) major surgery, trauma, or hospitalization; * Pregnancy, lactation, or childbearing potential without reliable contraception; * Body mass index (BMI) \<16 or \>40 kg/m²; * Current use of medications affecting muscle or nutritional metabolism (e.g., corticosteroids, anabolic steroids); * Participation in another interventional trial within 30 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Appendicular Skeletal Muscle Index | Day 180 ± 10 days | Appendicular Skeletal Muscle Index (ASMI) = appendicular lean mass (kg) / height² (m²). It reflects muscle mass, used for sarcopenia diagnosis. Lower values indicate muscle loss, linked to aging, malnutrition, or disease. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Handgrip strength | Day 180 ± 10 days | Handgrip strength (HGS) = maximum force (kg) measured by a dynamometer. It reflects overall muscle function, predicts disability, morbidity, and mortality. Low HGS indicates sarcopenia, frailty, or poor nutritional status. |
| Nutrition intake form（MNA） | Day 180 ± 10 days | Mini Nutritional Assessment - Short Form (MNA-SF) consists of 6 items: * Appetite and food intake - assesses whether food intake has decreased over the past 3 months. * Weight loss - records recent unintentional weight loss. * Mobility - determines whether the person can walk independently or is bedridden. * Acute disease or psychological stress - checks for stressful events in the past 3 months. * Neuropsychological problems - identifies dementia, depression, or other mental disorders that affect eating. * Body mass index (BMI) or calf circumference - reflects body fat reserves and muscle mass. Each item scores 0-3 points. A total score ≤11 indicates a risk of malnutrition. It is commonly used for nutritional screening in elderly populations. |
| Fried | Day 180 ± 10 days | Fried Frailty Phenotype = a 5-item scale assessing unintentional weight loss, exhaustion, low grip strength, slow walking speed, and low physical activity. item ≥3 = frail; 1-2 = prefrail; 0 = robust. Predicts falls, disability, and mortality. |
| FRAIL | Day 180 ± 10 days | FRAIL Scale = a 5-item questionnaire: Fatigue, Resistance (climb stairs), Ambulation (walk), Illness (≥5 chronic conditions), and Loss of weight (≥5%). Score 0 = robust, 1-2 = prefrail, 3-5 = frail. Quick screening for frailty in community settings. |
| SPPB | Day 180 ± 10 days | Short Physical Performance Battery (SPPB) = a 3-component test: standing balance (0-4), 4-meter gait speed (0-4), and 5-repetition chair stand (0-4). Total score 0-12; ≤8 indicates poor physical function, predicts disability, falls, and mortality in older adults. |
| Muscle mass measured by ultrasound | Day 180 ± 10 days | Ultrasound-based measurements of peripheral skeletal muscles offer a practical, non-invasive, and radiation-free approach for assessing muscle mass in clinical and research settings. In accordance with previously established cut-off values, the following parameters are employed to identify a tendency toward reduced muscle mass: 1. Biceps brachii cross-sectional area (CSA) - a male-specific indicator, with a value \< 7.1 cm² suggesting reduced muscle mass; 2. Tibialis anterior muscle thickness (MT) - a female-specific indicator, with a value \< 2.3 cm suggesting reduced muscle mass; 3. Rectus femoris muscle thickness (MT) - a gender-neutral rapid screening index, with a value \< 1.3 cm serving as a universal cut-off for both men and women, indicating a tendency toward low muscle mass. These ultrasonographic parameters are intended for initial screening and may assist in the early identification of individuals at risk for sarcopenia, particularly when access to dual-energy X-ray abs |
Countries
China
Contacts
CONTACTjin he hejin
Outcome results
None listed