Hemodynamic (MAP) Stability
Conditions
Brief summary
A difference exists in intraoperative hemodynamic stability and vasopressor requirement between the two techniques
Interventions
Patients (Selected for Unilateral Spinal Anaesthesia, UniSA) will be positioned laterally with the operative side dependent. Following aseptic preparation, Patient will be given a small volume of preload of Ringer Lactate (3-5ml /kg) i.e 250-300ml to avoid Spinal induced hypotension and to minimize fluid overload due to reduced ejection fraction. After giving preload, A 25-gauge Quincke needle will be introduced at the L3-L4 interspace, and 1.0 ml (7.5 mg) of 0.75% hyperbaric bupivacaine will be injected intrathecal. The lateral position will be maintained for approximately 10 minutes to achieve a unilateral block. Analgesia will also be maintained by using Ketorolac and Acetaminophen if there would be any complain of Pain. Continuous monitoring of HR, MAP, and SpO₂ will be undertaken to ensure stability
Anaesthesia induction will be achieved with IV propofol (1-2 mg/kg) and nalbuphine (0.1 mg/kg) for analgesia. Neuromuscular relaxation will be achieved with atracurium (0.5 mg/kg) and additional doses will be given as needed. Anaesthesia will be maintained with isoflurane in a mix of oxygen and air. If the heart rate or mean arterial pressure rises by more than 20% from baseline, an extra dose of nalbuphine (2 to 3 mg IV) will be given. Analgesia will also be maintained by using Ketorolac and Acetaminophen. At the end of surgery , Remaining muscular relaxation will be neutralized by administering neostigmine (0.05mg/kg)
Sponsors
Study design
Eligibility
Inclusion criteria
1\. Patient Age/Gender : 18-70 Years Male / Female. 2 Elective lower-limb surgery 3. Patients with reduced Ejection Fraction: rEF ( 35-40%) 4 ASA Class II-III
Exclusion criteria
1. Emergency surgery. 2. Coagulopathy. 3. Spinal deformity or infection. 4. Drug allergy. 5. Severe pulmonary disease VI. Psychiatric and Neurological Illness. VII. BMI \> 35 kg/m² VIII. Allergic to local anaesthetic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic stability | Hemodynamic will be monitor for 90 min |
| Intraoperative vasopressor requirement | Through out the surgery vasopressor requirement |
Countries
Pakistan