Opioid-Free Analgesia for Laparoscopic Cholecystectomy

Analgesic Efficacy of Opioid-Free Anesthesia Protocol Combined With Ultrasound-Guided External Oblique Intercostal Plane Block for Laparoscopic Cholecystectomy: A Prospective Randomized Comparative Study

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07750769

Enrollment

Registered

2026-08-06

Start date

2026-10-15

Completion date

2028-10-15

Last updated

2026-08-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgesia After Laparoscopic Cholecystectomy

Brief summary

laparoscopic cholecystectomy (LC) is often accompanied by moderate-to-severe postoperative pain. opioid-free anesthesia (OFA) consists of a variety of non-opioid narcotic drugs and techniques.

Detailed description

opioid-free anesthesia (OFA) can control postoperative pain effectively and reduce opioid drug consumption. The external oblique intercostal plane (EOI) block is easy to perform and may provide effective analgesia for laparoscopic cholecystectomy.

Interventions

PROCEDUREEOI with OFA

Patients will receive ultrasound-guided external oblique intercostal plane (EOI) block added to an opioid-free anesthesia (OFA) protocol

DRUGOFA

Patients will receive an opioid-free anesthesia (OFA) protocol

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Adult patients scheduled for elective laparoscopic cholecystectomy (LC) surgery under general anesthesia, American Society of Anesthesiologists (ASA) physical status I-II, aged from 18 to 65 years old of either sex

Exclusion criteria

* Contraindications to regional block (coagulopathy, infection at the needle insertion site, or known allergy to amide local anesthetics) * Pregnancy or breastfeeding women * Body mass index (BMI) \> 35 Kg/m2 * History of hepatic, renal, or cardiac disease * Chronic opioid use, or history of chronic pain (pain present for more than 6 months) * Thoracic deformity * Neuropsychiatric disorders * Patient refusal.

Design outcomes

Primary

Measure	Time frame	Description
the amount of fentanyl consumption used for pain relief in the first six hours after laparoscopic cholecystectomy (LC) under general anesthesia	The first six hours after surgery	Assessed in microgram

Contacts

CONTACTSeham M Moeen, M.D.

seham.moeen@aun.edu.eg01006386324

CONTACTMohamed R Shaaban, Msc.

mohamedrefaat@aun.edu.eg01140541916

PRINCIPAL_INVESTIGATORSeham Seham Moeen, M.D.

Assiut University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 7, 2026