Hyaluronic Acid vs I-PRF With Microneedling in Enhancing Peri-implant Soft Tissue

Hyaluronic Acid Versus I-PRF Combined With Microneedling for Peri Implant Soft Tissue Enhancement: A Randomized Controlled Clinical Trial

Status

Not yet recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07750756

Enrollment

Registered

2026-08-06

Start date

2026-10-30

Completion date

2028-05-30

Last updated

2026-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peri-implant Mucosa Thickness

Keywords

microneedling, hyaluronic acid, I-PRF, gingival thickness, peri-implant

Brief summary

This study aims to compare the use of microneedling alone versus with hyaluronic acid or i-PRF in conjunction with microneedling in peri-implant mucosa in the esthetic zone to test the superior increase in gingival thickness.

Detailed description

Despite the rising demand for esthetics and the prevailing use of dental implants in the recent era, the soft tissue remains a dilemma that affects patients' satisfaction and the implants' longevity in the oral environment, especially in the esthetic region of the maxilla. Various studies have been done to test the effectiveness of microneedling, hyaluronic acid, and i-PRF as alternative non-invasive or minimally invasive methods targeting tissue enhancement in the gingiva, and have proven that they have notable and desirable results. However, there is a lack in the literature regarding the use of these previously mentioned treatment options with regard to peri-implant soft tissue, and which of the delivered solutions offers superior results with reference to peri-implant mucosa in conjunction with microneedling.

Interventions

DRUGHyaluronic Acid (HA)

Hyaluronic acid (HA) is a genuine linear glycosaminoglycan that is present within the extracellular matrix of connective, epithelial, and neural tissues.

BIOLOGICALPlatelet rich fibrin

Injectable PRF (i-PRF) is a notable method in enhancing soft tissue phenotypes, relying on its injectable form that can be well delivered to targeted areas to ensure proper distribution of growth factors and cytokines.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

21 Years to 50 Years

Healthy volunteers

Inclusion criteria

* Patients with delayed implants placed in the maxillary esthetic region in correct positioning and angulation * Patients with peri-implant gingival thickness ≤ 1 mm * Patients with healthy gingiva and who can maintain good oral hygiene around implants

Exclusion criteria

* Marginal bone loss ≤ 2 mm * Patients with peri-implantitis or periodontitis * Patients with systemic conditions or diseases impairing healing or soft tissue metabolism * Pregnant or lactating females * Patients taking medications affecting the gingiva

Design outcomes

Primary

Measure	Time frame
Peri-implant gingival thickness	6 months

Contacts

CONTACTRahaf A. Khattab, Principal investigator

RahafZayn@dent.asu.edu.eg+201120008982

CONTACTDoaa A. Khattab, Associate Professor

doaadel12345@yahoo.com+201006814258

STUDY_CHAIRDoaa A. Khattab, Associate Professor

Ain Shams Univeristy

STUDY_DIRECTORSuzan Sarhan, Associate Professor

Ain Shams University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 18, 2026