Skeletal Class III Malocclusion
Conditions
Keywords
skeletal class III malocclusion, Genetic mutation, SNPs
Brief summary
Purpose of the Research: To reveal the genetic cause for the occurrence of Class III malocclusion, or what may be described as a reverse bite (underbite). Introduction and Detailed Procedures for the Patient (Work Plan): 1. The volunteer will rinse their mouth with chlorhexidine before taking the swab. 2. A saliva sample will be collected from the patient using a syringe, along with a frontal facial photograph and a lateral cephalometric X-ray. 3. DNA / genetic material will be extracted from the sample. 4. Screening will be conducted for genetic mutations that may be responsible for the occurrence of the underbite. 5. The photographs and X-rays will be analyzed and compared with the swab results. 6. This data will be analyzed to determine whether the detected mutations are the cause of the underbite. 7. The sample will be retained for use in future research studies. Side Effects, Expected Risk Levels, and Management" * Pain: Mild discomfort during swab collection, which does not require any painkillers. * Infection/Inflammation: Mild inflammation at the sample site or a secondary bacterial infection; in this case, antibiotics may be prescribed if necessary. * Risk Level: Low risk, estimated to be less than 5%.
Interventions
None listed
Sponsors
Cairo University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
10 Years to No maximum
Inclusion criteria
for Control group: * Patients of Egyptian nationality. * ANB from 0° to 4.8°.ANB from 0° to 4.8°. * Wits appraisal no less than -3.0 mm. Inclusion Criteria for Study group: * Patients of Egyptian nationality. * ANB (angle between point A, nasion and point B at nasion) angle (point A-nasion point B) of less than 0 degrees. * Negative Wits appraisal greater than -3.0 mm.
Exclusion criteria
* The presence of any growth disturbances, syndromes, congenital abnormalities, \& endocrine disorders. * Patients subjected to previous orthodontic, orthopedic, or orthognathic treatment. * Poor quality of radiographic records. * Consent form not signed. * Trauma.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| presence of single nucleotide polymorphism | cross-sectional - results are assessed at one point of time (Preintervention) | difference in snps between control and study group |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| lateral cephalometric measurements | cross-sectional - results are assessed at one point of time (Preintervention) | if the snps found have a correlation with different linear and angular measurements |
| Frontal photos measurements | cross-sectional - results are assessed at one point of time (Preintervention) | If the snps found have a correlation with different ratios on frontal photos: |
Countries
Egypt
Outcome results
None listed