Impacted Mandibular Third Molar Extraction
Conditions
Brief summary
This randomized double-blind clinical trial aims to evaluate the effects of titanium-prepared platelet-rich fibrin (T-PRF), low-level laser therapy (LLLT), and their combination on postoperative outcomes following surgical extraction of impacted mandibular third molars. Sixty patients will be randomly allocated to one of four parallel groups: T-PRF, LLLT, T-PRF plus LLLT, or control. The primary outcomes include postoperative pain assessed using a visual analogue scale (VAS), analgesic consumption, postoperative swelling and trismus. The findings may help identify effective approaches for improving postoperative recovery after mandibular third molar surgery.
Interventions
Titanium-prepared platelet-rich fibrin (T-PRF) was prepared from autologous blood and placed into the extraction socket immediately after mandibular third molar surgery.
Low-level laser therapy was applied using a 650 nm diode laser (25 mW) immediately after surgery and once daily for the following two postoperative days.
Sponsors
NEW Cyprus Health and Social Sciences University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Participants and the outcome assessor were blinded to treatment allocation. Randomization was performed using a lottery-based allocation method by an independent staff member. The operating surgeon, who performed the assigned intervention, was not involved in postoperative outcome assessment.
Eligibility
Sex/Gender
ALL
Age
18 Years to 31 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults requiring surgical extraction of a unilateral vertically impacted mandibular third molar. * Healthy individuals (ASA I or II). * Ability to provide written informed consent. * Willingness to attend all follow-up visits.
Exclusion criteria
* Systemic disease affecting wound healing. * Pregnancy or lactation. * Active infection or acute pericoronitis. * Long-term opioid use. * Smoking and alcohol use. * Known allergy to study medications. * Previous radiotherapy to the head and neck region * Inability to attend follow-up visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Pain | Postoperative Days 1, 2, 3, and 7 | Postoperative pain assessed using a 100-mm Visual Analog Scale (VAS). |
| Analgesic Consumption | Postoperative Days 1, 2, 3, and 7 | Number of analgesic tablets consumed after surgery. |
| Facial Swelling | Preoperative baseline and Postoperative Days 1, 2, 3, and 7 | Postoperative facial swelling will be evaluated using standardized linear facial measurements. Three distances will be measured with a flexible measuring tape: tragus to the corner of the mouth (Tragus-Commissure), tragus to the soft-tissue pogonion (Tragus-Pogonion), and lateral canthus of the eye to the mandibular angle (Lateral Canthus-Gonion). The sum of the three measurements (in centimeters) will be recorded for each participant. Higher values indicate greater postoperative facial swelling. |
| Maximum Interincisal Mouth Opening (Trismus) | Preoperative baseline and Postoperative Days 1, 2, 3, and 7 | Postoperative trismus will be evaluated by measuring the maximum interincisal mouth opening using a calibrated ruler. The distance (in millimeters) between the incisal edges of the maxillary and mandibular central incisors during maximum mouth opening will be recorded for each participant. Lower values indicate greater postoperative trismus. |
Countries
Turkey (Türkiye)
Outcome results
None listed