Improving Management of Recipients of Care With HIV Viremia to Optimize Viral Suppression in Zambia: A Process and Outcome Evaluation

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07747987

Enrollment

548

Registered

2026-08-05

Start date

2023-04-01

Completion date

2023-09-30

Last updated

2026-08-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV - Human Immunodeficiency Virus

Keywords

High Viral Load

Brief summary

The Centre for Infectious Disease Research in Zambia (CIDRZ) as an implementing partner (IP) through its Centers for Disease Control and Prevention (CDC) and President's Emergency Plan for AIDS Relief (PEPFAR)-funded programs provides technical assistance to the Zambian Ministry of Health (MOH) to support the 95-95-95 HIV care cascade targets. Following the expansion of the DSD approach to cover non-established PLHIV, the MOH, with assistance from CIDRZ piloted the introduction of viremic clinics (VCs) as a DSD model in Lusaka to manage recipients of care (ROCs) with unsuppressed viral loads. In this paper, we describe and report on the programmatic performance and outcomes of VL testing at 6 and 12-months in PLHIV on first line ART in the VC model programme in Lusaka province as well as identify the patient and healthcare workers facilitators and barriers to improve viral suppression within the VCs.

Detailed description

To review and understand the progress on management of viremic RoCs in PEPFAR supported HIV programs in three Districts in Lusaka province. This evaluation is essential to help facility staff to tailor client centered service delivery solutions to improve outcomes in HIV viremic clinics. Results from this evaluation will not only help the Ministry of health (MoH), CIDRZ and other implementing partners to make strategic decisions to maximize re-suppression in the high viral load cascade, but will help to improve the management of RoCs and inform national guidance and policy.

Interventions

OTHERadditional support

Assigned specific day for high viral load recipients of care with a team of Health care providers to provide additional support and manage patients.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Evaluation of outcome for veridic clinic implemented in Lusaka

Eligibility

Sex/Gender

ALL

Age

15 Years to No maximum

Healthy volunteers

Inclusion criteria

* RoCs will be included if they are aged 15 years and above , * Started first line ART before March 2020 * on ART at least 6 months of continuous ART treatment * With complete medical records in smart care, HVL registers and enrolled with HVL RoCs and active Inclusion criteria for IDIs: * RoCs in the qualitative evaluation clinics * Aged \>15 years old * having received EAC in the past 6 months. Inclusion criteria for FGDs : \- Health care workers involved in the care of those who are not virally suppressed (treatment supporters, EAC counselors, professional healthcare workers)

Exclusion criteria

\- ROCs\< 15 years,

Design outcomes

Primary

Measure	Time frame	Description
Viral suppression	3 to 6 months	Viral Load copies \< 1000 after 3 months off successful enhance adherence counselling in viremic clinic

Countries

Zambia

Contacts

PRINCIPAL_INVESTIGATORMicheal Herce, Medical Doctor, MPH

Centre for Infectious Disease Research in Zambia

PRINCIPAL_INVESTIGATORIzukanji Sikazwe, Medical Doctor