Comparative Efficacy of Therapeutic Ultrasound and Neurodynamic Techniques for Carpal Tunnel Syndrome

Comparative Study Of Ultrasound and Neurodynamic Technique For Patients With Carpal Tunnel Syndrome in Mild And Moderate Stag

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07743879

Enrollment

Registered

2026-08-04

Start date

2025-02-25

Completion date

2025-11-26

Last updated

2026-08-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carpal Tunnel Syndrome (CTS)

Keywords

therapeutic ultrasound, neurodynamic techniques, nerve conduction study, conservative management

Brief summary

This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome.

Detailed description

This three-arm parallel-group randomized controlled trial evaluated the comparative efficacy of therapeutic ultrasound (US), neurodynamic techniques (ND), and combined US plus ND in 60 participants with mild to moderate carpal tunnel syndrome over a 6-week intervention period. The primary outcomes measured were pain intensity via visual analog scale (VAS) and symptom severity and functional status using the Boston Carpal Tunnel Questionnaire (BCTQ). Secondary outcomes evaluated nerve conduction parameters including distal motor latency (DML), sensory latency (SL), and sensory nerve action potential (SNAP) amplitude.

Interventions

OTHERNeurodynamic Techniques

Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 65 Years

Healthy volunteers

Inclusion criteria

* Clinical diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological testing. * Age between 18 and 65 years. * Presence of symptoms (pain, numbness, tingling) for at least 3 months.

Exclusion criteria

* History of previous carpal tunnel release surgery or wrist trauma. * Corticosteroid injection into the wrist within the past 3 months. * Cervical radiculopathy, polyneuropathy, or other upper extremity neurological disorders. * Pregnancy or lactation. * Contraindications to therapeutic ultrasound (e.g., active infection, metallic implants in the treatment area, malignant tumors).

Design outcomes

Primary

Measure	Time frame	Description
Pain Intensity	Baseline and 6 weeks post-intervention	Measure Description: Measured using the unabbreviated Visual Analog Scale (VAS). This scale ranges from 0 to 10 cm, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate a worse outcome (greater pain intensity).
Symptom Severity	Baseline and 6 weeks post-intervention	Measure Description: Assessed using the unabbreviated Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (more severe symptoms).
Functional Status	Baseline and 6 weeks post-intervention	Measure Description: Assessed using Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-FSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (greater functional disability/impairment).

Countries

Yemen

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 5, 2026