Cognitive Dysfunction, Ehlers-Danlos Syndrome, Subjective Cognitive Complaints
Conditions
Keywords
Subjective cognitive complaints, Brain fog, Functional cognition, Occupational therapy, Cognitive rehabilitation, Ehlers-Danlos Syndrome
Brief summary
This pilot study will evaluate a comprehensive cognitive assessment approach and personalized neurocognitive telerehabilitation intervention for adults with subjective cognitive complaints (SCC). The study includes older adults with SCC and adults with Ehlers-Danlos Syndrome (EDS) and SCC. Participants will complete pre- and post-treatment assessments and receive a 6-week COG+OT telerehabilitation intervention that combines cognitive rehabilitation and occupational therapy strategies to support everyday functional cognition.
Interventions
BEHAVIORALCOG+OT Telerehabilitation
COG+OT is a personalized telerehabilitation program that combines cognitive rehabilitation and occupational therapy. Cognitive rehabilitation sessions focus on strategies for attention, memory, organization, planning, problem solving, and executive function. Occupational therapy sessions use meaningful daily activities to support application and generalization of cognitive strategies in home- and community-based tasks. The intervention is delivered remotely over 6 weeks in 10 sessions lasting approximately 45 to 60 minutes each.
Sponsors
Medical University of South Carolina
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
21 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Endorsement of subjective cognitive complaints as indicated by a score ≥4 on the Healthy Brain 9 (HB9) * Community-dwelling adult aged 60 years or older, or adult aged 21 years or older with a diagnosis of Ehlers-Danlos Syndrome (EDS) * English as the primary language * Access to and ability to use a smartphone compatible with the NeuroUX platform * Access to a device capable of supporting a telerehabilitation visit, such as a phone, tablet, or laptop, and a reliable Wi-Fi or cellular internet connection * Able to participate in study assessment sessions as determined by the licensed, experienced telerehabilitation occupational therapist
Exclusion criteria
* Diagnosis of dementia or mild cognitive impairment * Significant or unstable conditions or treatments for medical conditions that may impact cognition, such as traumatic brain injury or brain tumor * Inability to engage in study-related procedures as determined by the study team
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Everyday Cognition Scale-II (ECog-II) Score | Pre-treatment to post-treatment, approximately 8 weeks | Change in subjective cognition measured using the Everyday Cognition Scale-II (ECog-II), a self-report measure assessing perceived cognitive functioning across everyday activities, including memory, executive function, language, and attention. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Retention Rate | Through study completion, approximately 8 weeks | Feasibility measured as the percentage of participants who complete all study sessions. |
| Adherence Rate | Through study completion, approximately 8 weeks | Feasibility measured as the percentage of participants completing intervention activities for each session, including functional task practice and homework. |
Countries
United States
Contacts
CONTACTPatricia Finetto, OTR/L
CONTACTMichelle Woodbury, PhD, OTR/L
PRINCIPAL_INVESTIGATORMichelle Woodbury, PhD, OTR/L
Medical University of South Carolina
Outcome results
None listed