Auditory Brainstem Evoked Potentials in Autism Spectrum Disorder

Auditory Brainstem Evoked Potentials in Autism Spectrum Disorder: A Window on Neural Maturation and Sex Differences

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07743177

Enrollment

200

Registered

2026-08-03

Start date

2026-03-31

Completion date

2028-03-31

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autism Spectrum Disorder

Keywords

Autism Spectrum Disorder, Auditory Brainstem Evoked Potentials, Auditory Processing, Neurodevelopment

Brief summary

This retrospective study investigates auditory brainstem evoked potentials (BAEPs) in children with autism spectrum disorder (ASD) compared with other neuropsychiatric conditions. The study aims to evaluate differences in BAEP parameters, with particular attention to sex- and age-related effects and clinical severity

Detailed description

Autism spectrum disorder is a neurodevelopmental condition frequently associated with atypical sensory processing, particularly in the auditory domain. BAEPs provide an objective neurophysiological measure of auditory pathway integrity and maturation at the brainstem level. This study retrospectively analyzes BAEP recordings collected at IRCCS Fondazione Mondino between January 2021 and December 2023. Latencies of waves I, III, and V, as well as interpeak intervals (I-III, III-V, I-V), are compared between children with ASD and children with other neuropsychiatric conditions. Secondary analyses explore associations between BAEP parameters, ASD severity, age, and sex, in order to clarify potential neurobiological differences and evaluate BAEPs as candidate electrophysiological biomarkers for ASD.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

2 Years to 5 Years

Healthy volunteers

Inclusion criteria

* Children aged 2-5 years * BAEP examination performed at IRCCS Fondazione Mondino between January 2021 and December 2023 * Diagnosis/Suspicion of autism spectrum disorder or other neuropsychiatric conditions * Availability of technically reliable BAEP recordings

Exclusion criteria

* Non-interpretable BAEP recordings due to lack of cooperation

Design outcomes

Primary

Measure	Time frame	Description
Differences in BAEP interpeak intervals (I-III, III-V, I-V)	Single assessment at admission between 2021 and 2023 (retrospective analysis)	Differences in BAEP interpeak intervals (I-III, III-V, I-V) between children with ASD and other neuropsychiatric conditions
Differences in BAEP wave latencies (I, III, V)	Single assessment at admission between 2021 and 2023 (retrospective analysis)	Differences in BAEP wave latencies (I, III, V) and interpeak intervals (I-III, III-V, I-V) between children with ASD and other neuropsychiatric conditions

Secondary

Measure	Time frame	Description
BAEP parameters and ASD severity	Single assessment at admission between 2021 and 2023 (retrospective analysis)	Correlation between BAEP parameters and ASD severity
BAEP parameters and age	Single assessment at admission between 2021 and 2023 (retrospective analysis)	Correlation between BAEP parameters and age
BAEP parameters and sex	Single assessment at admission between 2021 and 2023 (retrospective analysis)	Correlation between BAEP parameters and sex

Countries

Italy

Contacts

PRINCIPAL_INVESTIGATORGiuseppe Cosentino, MD

Translational Neurophysiology

Outcome results