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Preoperative and Postoperative Refractive and Topographic Evaluation in Patients With Primary Pterygium: Comparison of Two Surgical Techniques

Preoperative and Postoperative Refractive and Topographic Evaluation in Patients With Primary Pterygium: A Comparison of Conjunctival Autograft and Amniotic Membrane Transplantation

Status
Completed
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07742995
Acronym
RETOP
Enrollment
78
Registered
2026-08-03
Start date
2013-04-01
Completion date
2015-03-01
Last updated
2026-08-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Pterygium, Astigmatism

Keywords

Primary Pterygium, Conjunctival Autograft, Amniotic Membrane Transplantation, Corneal Topography

Brief summary

This study evaluated changes in refractive status and corneal topography before and after surgical treatment of primary pterygium. Patients undergoing pterygium excision were treated with either conjunctival autograft or amniotic membrane transplantation. Visual acuity, refractive error, and corneal topographic parameters were assessed before surgery and after postoperative follow-up to compare the effectiveness of both surgical techniques in restoring corneal optics and improving visual outcomes.

Detailed description

Primary pterygium is a fibrovascular proliferation of the bulbar conjunctiva that extends onto the cornea and may induce significant refractive and topographic changes, resulting in visual impairment. Surgical excision is the treatment of choice for progressive lesions, with conjunctival autograft (CA) and amniotic membrane transplantation (AMT) representing two widely used techniques. Patients underwent conjunctival autograft or amniotic membrane transplantation based solely on the treating surgeon's clinical judgment, independently of study participation. The study did not assign surgical interventions. Patients were prospectively followed to compare refractive and corneal topographic outcomes between the two naturally occurring treatment cohorts. The primary objective was to compare postoperative refractive and topographic changes between the two surgical techniques. Secondary objectives included evaluating changes in visual acuity, corneal curvature, refractive astigmatism, topographic astigmatism, and identifying clinical factors associated with postoperative outcomes.

Interventions

Surgical excision of primary pterygium followed by transplantation of an autologous superior temporal conjunctival graft to cover the bare scleral bed.

Surgical excision of primary pterygium followed by placement of preserved amniotic membrane over the bare scleral bed.

Sponsors

Instituto de Oftalmología Fundación Conde de Valenciana
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Adults aged 18 years or older. * Diagnosis of primary nasal pterygium in one or both eyes. * Pterygium extending at least 1 mm onto the cornea. * Underwent primary pterygium excision with either conjunctival autograft (CAG) or amniotic membrane transplantation (AMT).

Exclusion criteria

* Corneal scars. * Corneal ectatic disorders. * History of ocular trauma. * Previous ocular surgery. * Cicatrizing ocular surface disease. * Cataract or any other ocular condition that could affect visual function.

Design outcomes

Primary

MeasureTime frameDescription
Change in Corneal Topographic AstigmatismBaseline and 12 months after surgeryComparison of the change in corneal topographic astigmatism from baseline to 12 months after pterygium excision between conjunctival autograft and amniotic membrane transplantation.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 18, 2026