Leukemia
Conditions
Keywords
seated exercise, Functional capacity, Quality of life, Chemotherapy, Exercise therapy
Brief summary
This study aims to evaluate the efficacy of seated exercise on functional capacity and quality of life in patients with leukemia during chemotherapy cycles Participants will receive efficacy of seated exercise on functional capacity and quality of life in patients with leukemia during chemotherapy cycles over a defined period. Outcomes will be assessed using Pulmonary function test, 6 min walk test and FACT- G questionnaire to determine improvements in quality of life in cancer patient rehabilitation special to diagnosed with leukemia.
Detailed description
Cancer is a major public health that gives an economical burden on the patient and government. The incidence of different types of cell tumors are increasing nowadays. Although chemotherapy is given to kill cancer cells, it also damage normal cells and cause significant side effects while others may have more. Some CT side effects can be severe enough to require hospitalization effects. CT affects patients functional capacity and quality of life next to the cancer it self. This study is designed as randomized controlled trial to assess the impact of seated exercise on functional capacity and quality of life in patient with leukemia during chemotherapy cycles. participants will be recruited from Hematology unit, Department of General Internal Medicine, Benha University Hospitals . The intervention protocol includes a-30 minutes seated exercise program three times a week with at least a one- day break between sessions for four weeks for the treatment group. Outcome measures will include maximum voluntary ventilation, 6 min walk test distance and FACT-G questionnaire before and after the exercise program. The program includes a five- minute warmup, 20 minutes of moderate-intensity repetitive motion exercise and a five- minute cool down. Ethical considerations: This study has been reviewed and approved by the Ethical Committee of Benha university. Written informed consent will be obtained from all participants or their legal guardians prior to treatment.
Interventions
BEHAVIORALSeated exercise
Participants in the intervention group will perform a structured seated exercise program during their chemotherapy cycles. The exercise program will consist of supervised, individualized seated exercises designed to improve functional capacity and quality of life. The exercise sessions will be performed according to the study protocol throughout the intervention period. Each session will consist of a five-minute warm up, 20 minutes of moderate intensity repetitive motion exercises, and a five -minute cool-down. Functional outcomes will be assessed before and after the exercise program. including maximum voluntary ventilation , six-minute walk test distance, and FACT- G quesionnaire.
Sponsors
Suez University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
MALE
Age
30 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
1. Male patients with age ranges from 30 to 40 years. 2. All patients in this study will be on chemotherapy from at least one cycle as a treatment of leukemia. 3. All patients will be hemodynamically stable. 4. Patients are ambulant.
Exclusion criteria
1. Lung cancer 2. History of any pulmonary disease. 3. Metastasis of lung , ribs and mediastinal structure. 4. Pulmonary pathology (e.g. acute respiratory distress syndrome, or exacerbation of chronic obstructive pulmonary disease). 5. Ruptured eardrum or any other condition of the ear. 6. Severe bronchospasm. 7. High peak air way pressure (barotraumas). 8. patients with marked elevated left ventricular end- diastolic volume and pressure. 9. patients with worsening haert failure signs and symptoms.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in functional capacity | Baseline and after 4 weeks of intervention | Functional capacity will be assessed by the six-minute walk test (6MWT) distance before and after the four week seated exercise programe. |
| change in quality of life | Baseline and after 4 weeks of intervention | Quality of life will be assessed using the Functional Assessment of Cancer Therapy General (FACT-G) questionnaire before and after week seated exercise programe. the total FACT-G score ranges from 0 to 108, with higher scores indicating better quality of life |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Maximum Voluntary Ventilation (MVV) | Baseline and after 4 weeks of intervention | Change in Maximum Voluntary Ventilation (MVV) will be assessed before and after the four week seated exercise program |
Outcome results
None listed