Hearing Disorders and Deafness
Conditions
Brief summary
The goal of this study is to identify electrical patterns in the cortex that enable the generation of predictions in natural auditory sequences such as speech and music. Between 500 and 700 participants in total (250 to 350 normally hearing participants (including 60 to 120 participants from West Africa and 60 to 120 participants from Western Europe) and 250 to 350 participants with hearing loss (no restrictions on origin)). Participants will listen to naturally recorded music and speech via headphones. They will be asked to rate these stimuli on a scale from 0 to 10 in terms of pleasure and comprehension, using a keyboard and mouse or voice input. Additionally, they will be required to sing or produce novel/improvised vocal responses using high-fidelity microphones. This entire procedure will be conducted under electroencephalography (EEG) to record neuronal responses throughout the process.
Interventions
None listed
Sponsors
Institut Pasteur
IHU reConnect
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
For hearing participants: * Average pure-tone thresholds ≤ 20 dB HL For participants with hearing loss: * Average pure-tone thresholds \> 20 dB HL For participants of West African origin: * Average pure-tone thresholds ≤ 20 dB HL * Declare that both parents are of West African origin, either by their own birth or by the birth of both of their parents.
Exclusion criteria
* No known neurological or audiological disorders * Participants under legal guardianship (tutelle, curatelle) * Participants deprived of legal liberty by judicial or administrative decision
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between neural recordings and IA models | Day 1 | To identify electrical patterns in cortex which generates predictions in natural auditory sequences (such as speak and music). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Compare predictions generated across different cultural contexts | Day 1 | specifically, comparing West African and Western European communities in Paris |
| Compare predictions for identical stimuli across repeated sessions to establish a link between processing and successful memorization/retention. | From enrollement to visit 2 (10 days) | — |
| Compare predictions generated between hearing individuals and those with hearing impairments. | Day 2 | — |
| Correlate predictive measures with responses to autism symptom questionnaires across the various experiments. | Day 1 | — |
Outcome results
None listed