Periodontitis on Gingival Crevicular Fluid Metobolomics

Impact of Periodontitis on Metabolomics in Gingival Crevicular Fluid

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07739732

Enrollment

Registered

2026-07-31

Start date

2026-05-04

Completion date

2026-12-18

Last updated

2026-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontitis

Brief summary

This cross-sectional observational study will compare the gingival crevicular fluid metabolomic profile of 30 adults with periodontitis and 30 periodontally healthy adults. Participants will undergo a periodontal examination and gingival crevicular fluid collection during a single study visit. Targeted metabolomic analysis will be used to identify differences between the two groups and associations with periodontal clinical parameters.

Detailed description

Sixty adults will be enrolled: 30 with periodontitis and 30 with periodontal health. Gingival crevicular fluid will be collected using four sterile absorbent paper strips inserted sequentially into the deepest eligible periodontal site or gingival sulcus. The strips will be pooled in a coded tube and stored immediately at -20 °C. Blood-contaminated samples will be discarded. Laboratory personnel will be blinded to group allocation. Targeted metabolomic findings will be compared between groups and correlated with periodontal clinical parameters.

Interventions

OTHERPeriodontal probing depth

Periodontal probing depth measured in millimeters

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

1. Age between 18 and 70 years. 2. Ability to understand the study procedures and provide written informed consent. 3. For the periodontitis group: diagnosis of periodontitis according to the 2018 classification of periodontal diseases. 4. For the healthy control group: periodontal health according to the 2018 classification, with no current diagnosis or history of periodontitis.

Exclusion criteria

1. Periodontal treatment during the previous 6 months. 2. Use of antibiotics, non-steroidal anti-inflammatory drugs, or immunosuppressive agents during the previous 6 months. 3. Pregnancy.

Design outcomes

Primary

Measure	Time frame
Probing pocket depth	Baseline

Countries

Italy

Contacts

CONTACTGaetano Isola

gaetano.isola@unict.it0953785652

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 1, 2026