Breast Cancer, Cancer
Conditions
Keywords
Exercise
Brief summary
In this study, the investigators hypothesize that observed intense resistance training with conditioning elicits similar changes in body composition, muscle mass, and blood pressure as that with cardiovascular training (or cardio) for women treated with breast cancer.
Interventions
BEHAVIORALResistance Training with Cardio
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to steady-state cardiovascular exercise. The cardio day will utilize ergometer-based exercises (rowing ergometer, Assault Air Bike) and unweighted sled pushes, with each activity lasting 10 minutes continuously. The overall program aims to improve cardiorespiratory fitness and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
BEHAVIORALResistance Training with Conditioning
Participants in this arm will engage in a supervised exercise regimen three times per week, for approximately 2 months (8 weeks). The regimen combines two days of hypertrophy-focused resistance training with a third day dedicated to high-intensity conditioning. The conditioning day involves a circuit format of 6 total exercises, completed for 8 repetitions each across 8 sets, with limited rest periods (10 seconds or less) between exercises and sets. Exercise selection is total-body focused, alternating between upper and lower body movements. The program aims to improve muscular conditioning and body composition in breast cancer survivors, under the guidance of Certified Strength and Conditioning Specialists (CSCS).
Sponsors
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 89 Years
Healthy volunteers
No
Inclusion criteria
1. Age 20-89 years 2. Women prescribed exercise as a SOC 3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast 4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed. 5. Women with \> 3 months of resistance training experience under expert guidance by a CSCS 6. Must be able to read and understand English and consent for themselves.
Exclusion criteria
1. Any current treatment with cytotoxic chemotherapy for breast cancer 2. Inability to safely engage in group sessions of resistance training as deemed by study PI 3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by PI to be unsafe to engage in resistance training 4. Beta blocker or GLP-1 inhibitor medications 5. Pregnant women 6. Males
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Muscle Mass | Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). | Measured as total muscle mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for muscle tissue thickness. |
| Change in Fat Mass | Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). | Measured as total fat mass (kg), determined via InBody 970 bioimpedance analysis and ultrasound (BodyMetrix) for adipose tissue thickness. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Blood Pressure | Baseline (Prior to Program), at Month 1, and At Exercise Program Completion (approximately 2 months). | Pre-workout blood pressure (systolic and diastolic) measurements. |
| Change in Resting Metabolic Rate | At Exercise Program Completion (approximately 2 months). | Resting metabolic rate (RMR) at the completion of the exercise regimen. |
| Change in Body Composition Metrics (Other than Muscle/Fat Mass) | Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). | Includes body mass, % fat, and % fat-free mass, measured via InBody 970 bioimpedance analysis. |
| Change in Phase Angle | Baseline (Prior to Program) and At Exercise Program Completion (approximately 2 months). | Phase angle, determined via InBody 970 bioimpedance analysis. |
| Exercise Adherence | Throughout the Exercise Program (approximately 2 months). | Defined as the number of sessions attended out of total sessions, as recorded by attendance logs. |
| Change in Grip Strength | Baseline (Prior to Program), During Exercise Program (before and after each workout), and At Exercise Program Completion (approximately 2 months). | Grip strength assessed via Jamar Hand Dynamometer bilaterally (three consecutive measures per hand). |
Countries
United States
Contacts
CONTACTClinical Trials Contact
PRINCIPAL_INVESTIGATORColin Champ, MD, CSCS
AHN Radiation Oncology
Outcome results
None listed