Bilateral Cochlear Implants, Congenital Hearing Loss
Conditions
Brief summary
Children with severe-to-profound congenital hearing loss often experience significant language development challenges. While cochlear implants (CIs) can restore auditory input, outcomes vary widely, even among those who receive implants early (before age 2) and undergo consistent speech therapy. This study aims to identify neural mechanisms underlying these differences.
Interventions
None listed
Sponsors
Institut Pasteur
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Between 4 and 17 years old at time of inclusion * Age of first implantation less than or equal to 30 months * Bilateral CIs * Received CIs simultaneously or sequentially (the interval between two implantations does not exceed 18 months) * Congenital severe-to-profound hearing loss (PTA ≥90 dB HL)
Exclusion criteria
* Children with severe associated disabilities who are assessed as unable to complete the tasks * Patients who, in the medical opinion of the Investigator, are unlikely to comply with the study protocol
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The beta coefficient of theta-gamma phase-amplitude coupling (PAC) in the linear mixed-effect model | at enrollment | language composite score is the dependent variable |
Secondary
| Measure | Time frame |
|---|---|
| Power-spectrum density (PSD) of the EEG resting-state oscillations | at enrollment |
| peak frequencies of the EEG resting-state oscillations | at enrollment |
| Multivariate temporal response functions (mTRF) in audiovisual and audio conditions | at enrollment |
| Comparison of the 40Hz Auditory steady-state responses (ASSR) between participants with or without GJB2 variant | at enrollment |
Outcome results
None listed