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Assessment of Post-Operative Pain After Using Cryotherapy and Dexamethasone

Assessment of Post-Operative Pain After Using Cryotherapy and Dexamethasone in Symptomatic Irreversible Pulpitis With Acute Apical Periodontitis: A Randomized Clinical Trial.

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07738302
Enrollment
60
Registered
2026-07-31
Start date
2026-08-01
Completion date
2026-09-01
Last updated
2026-07-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Pain

Brief summary

Evaluation and comparing the effect of cryotherapy and dexamethasone on inflammatory mediators and post-operative pain in symptomatic irreversible pulpitis with acute apical periodontitis.

Detailed description

sixty patients with single root teeth diagnosed with symptomatic irreversible pulpitis with acute apical periodontitis will be treated in two visits with time interval 72 hrs. Later, they will be randomized into four groups according to the type of irrigant used, group (A): (cold NaOCl , dexamethasone) for 1st visit and cold saline as final rinse for 2nd visit, group (B): ( NaOCl, dexamethasone) for 1st visit and saline as final rinse for 2nd visit (room temperature), group (C): cold NaOCl and cold saline and group D: NaOCl and saline room temperature as control group. Each group will be prepared with trunatomy rotary files according to manufactures instruction. Inflammatory mediators IL-8 and substance P will be assessed by absorbent paper points after access preparation and before obturation using ELISA test. Post-operative pain will be measured after first visit at 6,12, 24,48,72 hrs. then after second visit at 12,24,48,72hrs and 7 days using the visual analogue scale.

Interventions

COMBINATION_PRODUCTcold NaOCl , dexamethasone

irrigation solution

COMBINATION_PRODUCTNaOCl, dexamethasone

irrigation solution

COMBINATION_PRODUCTcold NaOCl and cold saline

irrigation solution

COMBINATION_PRODUCTNaOCl and saline

irrigation solution

Sponsors

Suez Canal University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No

Inclusion criteria

* Medically free Patients. (ASA I and II) * Age between 20-50 years old. * Males \& Females. * Patients' acceptance for participating in the trial through an informed consent (Appendix I) * Diagnosed clinically and radiographically with symptomatic irreversible pulpitis with apical peridontitits * No periapical radiolucency * Patent canals with n

Exclusion criteria

Non restorable teeth. * No bleeding upon conducting access preparation. * Teeth presenting with: * History of trauma or previous endodontic treatment

Design outcomes

Primary

MeasureTime frameDescription
post-operative pain7 daysVAS scale (visual analogue scale)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 1, 2026