Obesity & Overweight
Conditions
Keywords
obesity, monounsaturated fatty acids, pecans, cardiometabolic health, inflammation, dietary intake
Brief summary
You are invited to participate in a research study being conducted by Karen Gibson, Maria Morgan-Bathke, Dana Swope, Grace Huebner, Rebecca Brannan, Samuel McCormick at Viterbo University. The purpose of this research is to determine the effectiveness of using nuts and avocados as a dietary intervention on improving fasting blood glucose, lipid profile, energy expenditure, and body composition on pre-diabetic individuals compared to a control group. We hope to learn if a dietary intervention of nuts or avocado can help improve blood sugar, lipid panel and/or body composition. You were selected as a possible participant in this study because you have been diagnosed with pre-diabetes. If you decide to participate, you will be asked to complete an initial two hour appointment, follow the protocol of one of the interventions (one avocado or 1 ½ ounce nuts) and control group with only dietary counseling provided) daily for an eight week period, weekly telephone and/or email nutrition counseling, and attend a final two hour appointment. The food for the intervention (avocados and nuts) will be provided by the researchers and will not need to be purchased by the participants. The initial and final two hour appointments will consist of the following measurements: An overnight fast, blood glucose, cytokine level, and lipid panel tests will be completed by a venous blood draw. Then Maltron scan (to measure body composition, which in non-invasive and uses electrodes on the skin), waist/hip measurements, height/weight, and VioCare food frequency questionnaire will be completed. Following these screening measurements, a COSMED test to determine resting energy expenditure (REE) will be measured. It may take approximately 10 weeks from beginning to completion of this study.
Interventions
1.5 oz of pecans daily
Sponsors
Study design
Eligibility
Inclusion criteria
\- BMI of 25.0-40.0
Exclusion criteria
* BMI below 25.0 or over 40.0 * anyone who works a 3rd shift * pregnant and breastfeeding women * those with pre-existing chronic conditions * those with a latex allergy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| body composition | 10 weeks | percentage body fat |
| fasting blood glucose | 10 weeks | fasting blood glucose in mg/dl |
| weight | 10 weeks | weight in kg |
| height | 10 weeks | height in meters |
| total cholesterol | 10 weeks | total cholesterol in mg/dl |
| LDL cholesterol | 10 weeks | LDL cholesterol in mg/dl |
| HDL | 10 weeks | HDL cholesterol in mg/dl |
| TG | 10 weeks | triglycerides in mg/dl |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| inflammation | 10 weeks | circulating inflammation via plasma TNF-alpha in pg/ml |
| anti-inflammatory | 10 weeks | circulating inflammation via plasma IL-10 in pg/ml |
Contacts
Viterbo University