Alcohol Misuse, HIV (Human Immunodeficiency Virus), STI
Conditions
Keywords
HIV transmission, sexually transmitted infections, personalized normative feedback, social norms, HIV prevention, alcohol use
Brief summary
Randomized controlled trial to test the preliminary efficacy and mediating mechanism of a personalized normative feedback intervention on behavioral intentions, heavy alcohol use, and HIV/STI prevention among adolescents and young adults in Rwampara District, Uganda.
Detailed description
New approaches to HIV prevention and treatment among young people in HIV-endemic African countries will be needed to meet the 95-95-95 UNAIDS targets. Several HIV/STI transmission-related behaviors are more likely to occur with heavy alcohol use including engaging in condomless sex, partner concurrency, and transactional sex. Heavy alcohol use is a prevalent and strong modifiable risk factor for HIV transmission risk behavior in Uganda. One way to target behaviors related to HIV/STI-transmission, alcohol misuse, and their intersection is to target misperceived norms, which are directly linked to personal health behavior. This study employs a randomized controlled trial to evaluate how providing accurate information about local descriptive (i.e., behavioral) and injunctive (i.e., attitudinal) norms to adoloescents and young adults affect HIV/STI transmission behaviors and alcohol misuse. Participants are randomly assigned to one of four treatment arms: (1) a control condition without any normative information; (2) a treatment condition in which they are reminded of what they thought local HIV/STI transmission behavior engagement rates were in their school and then receive accurate information about rates of HIV/STI transmission behavior engagement and prevention in their school; (3) a treatment condition in which they are reminded of what they thought alcohol misuse rates were in their school and then receive accurate information about rates of alcohol misuse behavior in their school; or (4) a treatment condition in which they are reminded of what they thought alcohol misuse rates and local HIV/STI transmission behavior engagement rates were in their school and then receive both types of accurate normative information in their school. The study assesses how providing this type of personalized normative feedback within cohort-based data collection affects alcohol use and engagement in HIV/STI transmission behaviors, such as condomless sex, transactional sex, and drug/alcohol use during sexual activity. Outcomes will be measured through self-reported data at two time points within 12 months through two follow-up survey waves, which will be compared to baseline self-reported data before exposure to the PNF treatment. We hypothesize that providing accurate information about alcohol misuse and HIV/STI transmission and prevention behavior engagement rates will decrease alcohol misuse, decrease engagement in HIV/STI-transmission behavior and increase prevention behavior (primary outcomes), and improve the accuracy of estimated school level rates of engagement in HIV/STI transmission behaviors and alcohol misuse in the future (secondary outcome).
Interventions
BEHAVIORALPNF - HIV norms
As this is a survey experiment, the "intervention" involves random assignment to a survey questionnaire with specific treatments. This treatment is a survey-based questionnaire with a prompt stating the participant's previously provided estimate of engagement in HIV-transmission behavior engagement in their school. Participants are then provided with the true rates of HIV-transmission behavior engagement in their school, and notification that this is consistent across demographic groups. Two follow-up waves of survey collection over the 12 months following the PNF will collect information about engagement in HIV/STI transmission and prevention behaviors and alcohol misuse, which will be compared to baseline data collected before treatment.
BEHAVIORALPNF - Alcohol use norms
As this is a survey experiment, the "intervention" involves random assignment to a survey questionnaire with specific treatments. This treatment is a survey-based questionnaire with a prompt stating the participant's previously provided estimate of rates of alcohol use in their school. Participants are then provided with information about the true rates of alcohol use in their school. Two follow-up waves of survey collection over the 12 months following the PNF will collect information about engagement in HIV/STI transmission and prevention behaviors and alcohol use, which will be compared to baseline data collected before treatment.
BEHAVIORALPNF - HIV and alcohol use norms
As this is a survey experiment, the "intervention" involves random assignment to a survey questionnaire with specific treatments. The fourth treatment is a survey-based questionnaire with a prompt stating the participant's previously provided estimate of HIV transmission behavior engagement and alcohol use in their school. Participants are then provided with information about the true rates of both HIV transmission behavior engagement and alcohol use in their school. Two follow-up waves of survey collection over the 12 months following the PNF will collect information about engagement in HIV/STI transmission and prevention behaviors and alcohol use, which will be compared to baseline data collected before treatment.
Sponsors
Vanderbilt University
Mbarara University of Science and Technology
Vanderbilt University Medical Center
University of California, San Francisco
Massachusetts General Hospital
Brown University
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
13 Years to 25 Years
Healthy volunteers
Yes
Inclusion criteria
* All students enrolled in Kinoni High School, Kinoni Girls Secondary School, or Rugando Technical Institute, 13-25 years of age
Exclusion criteria
* Persons with psychosis, neurological damage, acute intoxication, or other cognitive impairment (all of which are determined informally in the field by non-clinical research staff in consultation with a supervisor)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Self-reported engagement in partner concurrency | Assessed at 3 months and 9 months after the intervention via follow-up survey. | — |
| Self-reported recent engagement in condomless sex | Assessed at 3 months and 9 months after the intervention via follow-up survey. | — |
| Self-reported engagement in alcohol use | Assessed at 3 months and 9 months after the intervention via follow-up survey. | Measured through the participant's self reported AUDIT-C score. |
| Self-reported HIV testing | Assessed at 3 months and 9 months after the intervention. | — |
| Self-reported alcohol/drug use during sex | Assessed at 3 months and 9 months after the intervention via follow-up survey. | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-reported engagement in transactional sex | Assessed at 3 months and 9 months after the intervention via follow-up survey. |
| Self-reported PrEP willingness/stigma/interest | Assessed at 3 months and 9 months after the intervention via follow-up survey. |
| Self-reported engagement in other sexual behaviors | Assessed at 3 months and 9 months after the intervention via follow-up survey. |
| Self-reported perception of school-level rates of HIV/STI transmission and prevention behaviors and attitudes | Assessed at 3 months and 9 months after the intervention via follow-up survey. |
| Self-reported perception of school-level rates of engagement in alcohol use | Assessed at 3 months and 9 months after the intervention via follow-up survey. |
Countries
Uganda
Contacts
CONTACTJessica M. Perkins, Ph.D.
CONTACTSarah E Sowell, B.A.
Outcome results
None listed