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Effects of Clamshell Exercises in Addition to Standardized Physical Therapy in the Management of Patellofemoral Pain Syndrome

Effects of Clamshell Exercises in Addition to Standardized Physical Therapy in the Management of Patellofemoral Pain Syndrome. A Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07730437
Enrollment
40
Registered
2026-07-28
Start date
2026-01-10
Completion date
2026-06-10
Last updated
2026-07-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anterior Knee Pain, Patellofemoral Pain Syndrome

Keywords

Patellofemoral Pain Syndrome (PFPS), Anterior Knee Pain, Clamshell Exercise, Hip Abductor Strengthening

Brief summary

This randomized controlled trial aims to evaluate whether adding clamshell exercises to standardized physical therapy provides greater improvements in pain and knee function than standardized physical therapy alone in individuals with patellofemoral pain syndrome (PFPS). PFPS is a common musculoskeletal condition characterized by pain around or behind the kneecap that is aggravated by activities such as stair climbing, squatting, running, and prolonged sitting. Participants aged 18-45 years with clinically diagnosed PFPS will be randomly assigned to one of two groups. The control group will receive standardized physical therapy consisting of warm-up exercises, stretching, quadriceps and lower-limb strengthening exercises, and cool-down activities. The experimental group will receive the same standardized physical therapy program with the addition of clamshell exercises targeting the gluteus medius and hip external rotator muscles. Both groups will participate in supervised treatment sessions lasting approximately 45 minutes, three times per week, for four weeks. Pain intensity will be measured using the Numeric Pain Rating Scale (NPRS), and knee function will be assessed using the Kujala Anterior Knee Pain Scale before and after the intervention. The findings of this study may help determine whether incorporating clamshell exercises into routine physiotherapy improves rehabilitation outcomes for patients with PFPS.

Detailed description

Patellofemoral pain syndrome (PFPS) is one of the most common causes of anterior knee pain, affecting both physically active individuals and the general population. The condition is associated with pain during activities that increase patellofemoral joint loading, including squatting, stair climbing, running, jumping, and prolonged sitting. Altered lower-limb biomechanics, particularly weakness of the hip abductors and external rotators, may contribute to excessive femoral internal rotation and dynamic knee valgus, thereby increasing patellofemoral joint stress. Conventional physiotherapy for PFPS typically includes stretching, quadriceps strengthening, and functional rehabilitation. Although these interventions are beneficial, many patients continue to experience persistent symptoms or recurrence. Recent evidence suggests that strengthening the hip musculature, particularly the gluteus medius, may improve lower-limb alignment and reduce patellofemoral joint stress. The clamshell exercise is a simple, low-cost exercise designed to activate the hip abductors and external rotators and may provide additional clinical benefit when combined with standard physiotherapy. The purpose of this randomized controlled trial is to determine whether adding clamshell exercises to standardized physical therapy results in greater reductions in pain and improvements in knee function compared with standardized physical therapy alone in patients with PFPS. Participants aged 18-45 years who meet the American Physical Therapy Association clinical diagnostic criteria for PFPS and have symptoms lasting at least three months with a pain score of 3 or higher on the Numeric Pain Rating Scale (NPRS) will be recruited. Participants with previous knee surgery, significant ligament or meniscal injuries, patellar dislocation, osteoarthritis, lumbar radiculopathy, hip pathology, systemic inflammatory arthritis, recent corticosteroid injection or surgery, neuromuscular disorders, pregnancy, or other exclusion criteria will not be eligible. Approximately 40 participants will be enrolled using purposive sampling after accounting for potential loss to follow-up. Participants will be randomly allocated into one of two treatment groups: Control Group: Standardized physical therapy. Experimental Group: Standardized physical therapy plus clamshell exercises. Both groups will receive equal treatment duration of approximately 45 minutes per session, three sessions per week for four weeks. Standardized physical therapy includes warm-up activities, stretching of the hamstrings, quadriceps, gastrocnemius-soleus complex, and iliotibial band, quadriceps and lower-limb strengthening exercises, and cool-down stretching. The experimental group will additionally perform side-lying clamshell exercises (3 sets of 12-15 repetitions) during each treatment session. Outcome assessments will be performed at baseline and after completion of the intervention. Pain intensity will be evaluated using the Numeric Pain Rating Scale (NPRS), while knee function will be assessed using the Kujala Anterior Knee Pain Scale. Statistical analyses will be conducted using SPSS version 27. Appropriate parametric or non-parametric tests will be selected based on data distribution, with statistical significance established at p \< 0.05. Ethical approval will be obtained from the Research Ethics Review Committee of Ibadat International University, Islamabad, and permission will be obtained from Alkhidmat Hospital, Peshawar. Written informed consent will be obtained from all participants before enrollment. Participant confidentiality will be maintained throughout the study, and participation will be voluntary with the right to withdraw at any stage without penalty.

Interventions

BEHAVIORALStandardized Physical Therapy with Clamshell Exercise

Participants perform side-lying clamshell exercises to strengthen the gluteus medius and hip external rotator muscles. The exercise is performed as 3 sets of 12-15 repetitions under physiotherapist supervision. This intervention is added to standardized physical therapy in the experimental group, resulting in a total treatment time of approximately 45 minutes per session, three sessions per week for four weeks.

Standardized physical therapy consists of warm-up exercises, stretching of the hamstrings, quadriceps, gastrocnemius-soleus, and iliotibial band, quadriceps and lower-limb strengthening exercises (including static quadriceps exercises, straight leg raises, hip strengthening exercises, and mini-squats), followed by cool-down stretching. The control group receives this intervention for approximately 35 minutes per session, three sessions per week for four weeks.

Sponsors

Ibadat International University, Islamabad
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)

Masking description

This is a single-blind randomized controlled trial. The outcome assessor will be blinded to treatment allocation to minimize assessment bias. Due to the nature of the exercise interventions, the treating physiotherapist cannot be blinded. Participants will not be informed of the study hypothesis or comparative purpose of the interventions, although complete blinding of participants is not feasible.

Intervention model description

Participants will be randomly assigned to one of two parallel groups. The control group will receive standardized physical therapy for 35 minutes per session, while the experimental group will receive standardized physical therapy plus clamshell exercises for a total of 45 minutes per session. Both groups will attend supervised treatment sessions three times per week for four weeks. Outcomes will be compared between groups at baseline and after completion of the intervention.

Eligibility

Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
No

Inclusion criteria

* Adults aged 18 to 45 years. Male or female participants. Clinically diagnosed with patellofemoral pain syndrome (PFPS) according to the American Physical Therapy Association (APTA) clinical practice guidelines. Presence of retropatellar or peripatellar pain. Reproduction of retropatellar or peripatellar pain during squatting or other functional activities that load the patellofemoral joint in knee flexion. Symptoms present for at least 3 months. Pain intensity of ≥3 on the Numeric Pain Rating Scale (NPRS) during aggravating activities. Able and willing to provide written informed consent and comply with the study procedures.

Exclusion criteria

* History of knee surgery, ligament injury, meniscal tear, patellar dislocation, or knee osteoarthritis. Lumbar radiculopathy, hip pathology, or systemic inflammatory arthritis (e.g., rheumatoid arthritis). Corticosteroid injection or knee surgery within the previous 3 months. Neuromuscular disorders affecting muscle function (e.g., stroke or Parkinson's disease). Pregnancy or within 6 months postpartum. Family history of early degenerative joint disease. Any condition that, in the investigator's opinion, would interfere with safe participation or completion of the study.

Design outcomes

Primary

MeasureTime frameDescription
Change in Pain Intensity Measured by the Numeric Pain Rating Scale (NPRS)Baseline and Week 4 (end of intervention)Pain intensity will be assessed using the 11-point Numeric Pain Rating Scale (NPRS), where 0 indicates no pain and 10 indicates the worst imaginable pain. The primary outcome is the change in NPRS score from baseline to the end of the intervention.

Secondary

MeasureTime frameDescription
Change in Knee Function Measured by the Kujala Anterior Knee Pain ScaleBaseline and Week 4 (end of intervention)Knee function will be evaluated using the Kujala Anterior Knee Pain Scale, a validated patient-reported outcome measure assessing symptoms and functional limitations associated with patellofemoral pain syndrome. The secondary outcome is the change in Kujala score from baseline to the end of the intervention.

Countries

Pakistan

Contacts

PRINCIPAL_INVESTIGATORDr Muhammad Nazim Farooq Dean, Phd

Ibadat International University, Islamabad

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 29, 2026