Childhood Hematopoietic and Lymphatic System Neoplasm, Childhood Malignant Solid Neoplasm
Conditions
Brief summary
This clinical trial tests the feasibility and acceptability of the Strengthening Teen Brain Resilience Using Music (STRUM) intervention to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment. Adolescents treated with radiation therapy for cancer often experience persistent cognitive deficits and reduced brain resilience or the ability to preserve cognitive and emotional functioning despite stressors. Musical instrument training has been shown to enhance memory, academic skills, and emotional well-being in youth. Although guitars are often the most preferred instrument, ukuleles offer greater accessibility due to their simplicity, affordability, and suitability for younger users. The STRUM intervention consists of virtual active music therapy ukulele lessons, which may be a feasible and acceptable way to improve radiation induced cognitive decline for adolescents undergoing radiation therapy for cancer treatment.
Interventions
OTHERInterview
Ancillary studies
PROCEDUREMusic Therapy
Attend STRUM sessions
OTHERSurvey Administration
Ancillary studies
Sponsors
Mayo Clinic
National Cancer Institute (NCI)
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
12 Years to 17 Years
Healthy volunteers
No
Inclusion criteria
* Aged 12-17 years at the time of enrollment * Receiving initial radiation therapy (RT) for cancer treatment with curative intent at the Mayo Clinic Arizona * Able to provide assent * Able to read and write in English * Have access to an electronic device with videoconferencing capability
Exclusion criteria
* Less than three-month prognosis * Past history of RT * Self-reported visual, hearing, or cognitive impairment impeding the ability to complete the STRUM intervention * Prior receipt of ukulele or guitar lessons * Actively receiving musical instrument lessons
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of eligible participants who consent to participate in this study (feasibility) | At time of enrollment | Feasibility defined as achieving a ≥ 70% consent rate among eligible participants. |
| Proportion of Strengthening Teen Brain Resilience Using Music (STRUM) sessions completed (feasibility) | Up to 10 weeks | Participants will receive 10 weekly 30-minute virtual ukulele lessons over ten weeks. Basic descriptive statistical analyses will be performed. |
| Average weekly practice minutes | Up to 10 weeks | Assessed by patient self-report. Participants will be encouraged to practice their skills independently for at least 90 minutes per week. Basic descriptive statistical analyses will be performed. |
| Percentage of participants who complete ≥ 90% of the measures at each timepoint (feasibility) | Baseline, week 6, week 12, week 20 | Basic descriptive statistical analyses will be performed. |
| Acceptability of the STRUM intervention | Approximately 2 weeks following end of intervention (week 12) | Defined as mean Acceptability of Intervention Measure (AIM) score of ≥ 3/4, supported by exit interview feedback. Basic descriptive statistical analyses will be performed. The AIM is a study-specific measure that consists of 4 questions, each answered on a scale of 1 (completely disagree) to 5 (completely agree). Higher scores indicate greater acceptability. |
| Participant perspective on meaningfulness of the STRUM intervention | Approximately 2 weeks following end of intervention (week 12) | Assessed by exit interview feedback. Participants will complete semi-structured exit interviews (approximately 30-minute duration). Exit interview transcripts will be analyzed and coded using thematic analyses. Thematic findings will be used to refine the intervention design and delivery. |
Countries
United States
Contacts
CONTACTRobert Bennett, PhD, RN
PRINCIPAL_INVESTIGATORC. Robert Bennett, PhD, RN
Mayo Clinic
Outcome results
None listed