Capsule Opacification, Ocular Hypertension
Conditions
Keywords
Posterior Capsule Opacification, Timolol Maleate, Intraocular Pressure, Posterior Capsulotomy, Neodymium-Doped Yttrium Aluminum Garnet Laser
Brief summary
This randomized controlled trial evaluated whether a single drop of 0.5% timolol maleate, administered before neodymium-doped yttrium aluminium garnet (Nd:YAG) laser posterior capsulotomy, reduced the rise in intraocular pressure compared with standard care alone. The study included adults aged 18-65 years who had developed posterior capsular opacification at least 3 months after cataract surgery and were scheduled to undergo Nd:YAG laser posterior capsulotomy. Participants were randomly assigned to receive either prophylactic topical timolol maleate or standard care without prophylactic timolol. Intraocular pressure was measured before the laser procedure and again 1 hour after the procedure by an ophthalmologist who was unaware of the assigned treatment. The study was based on the hypothesis that mean intraocular pressure 1 hour after posterior capsulotomy would be lower among participants who received prophylactic timolol maleate than among those who received standard care alone.
Interventions
DRUGTimolol Maleate
One drop of 0.5% timolol maleate ophthalmic solution was administered topically immediately before Nd:YAG laser posterior capsulotomy.
DRUGNo intervention
No prophylactic intraocular pressure-lowering medication was administered before Nd:YAG laser posterior capsulotomy.
Sponsors
CMH Multan Institute of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18-65 years * Male or female participants * Diagnosed with posterior capsule opacification after cataract surgery * Posterior capsule opacification present for at least 3 months * Scheduled to undergo Nd:YAG laser posterior capsulotomy
Exclusion criteria
* History or documented diagnosis of glaucoma * Baseline intraocular pressure greater than 21 mmHg before the procedure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean Intraocular Pressure 1 Hour After Nd:YAG Laser Posterior Capsulotomy | 1 hour after Nd:YAG laser posterior capsulotomy | Intraocular pressure was measured in millimetres of mercury using a Canon non-contact tonometer. The mean intraocular pressure measured 1 hour after Nd:YAG laser posterior capsulotomy was compared between participants who received one drop of 0.5% topical timolol maleate before the procedure and participants who received standard care without prophylactic timolol. |
Countries
Pakistan
Contacts
PRINCIPAL_INVESTIGATORIfrah Idress Lodhi
CMH Institute of Medical Sciences
Outcome results
None listed