Sepsis
Conditions
Brief summary
Objective: To investigate the correlation of PyroEVs and PLIN3 with the severity and prognosis of sepsis patients. Participants: Sepsis patients meeting the Sepsis 3.0 diagnostic criteria admitted to the Intensive Care Unit of Zhongda Hospital affiliated with Southeast University, as well as healthy volunteers. Inclusion Criteria: 1. Presence of confirmed or suspected infection; 2. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; 3. Signed informed consent. Exclusion Criteria: Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury. Primary outcome: 28-day mortality, SOFA score
Interventions
OTHERNo Intervention: Observational Cohort
No intervention
Sponsors
Zhongda Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* a. Presence of confirmed or suspected infection; b. Sequential Organ Failure Assessment (SOFA) score increase ≥ 2 points from baseline; c. Signed informed consent.
Exclusion criteria
* Age \< 18 or \> 80 years, pregnancy, cancer patients, and individuals with diseases potentially complicated by vascular endothelial cell injury.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of pyroptic extracellular vesicles (PyroEVs) in plasma | Day 1 | The concentration of pyroptic extracellular vesicles (PyroEVs) in plasma will be measured using nanoparticle tracking analysis. Results will be reported as particles per milliliter (particles/mL). |
| Concentration of PLIN3 in plasma | Day 1 | — |
| 28-day mortality | 28 days | — |
| SOFA score | 28 days | — |
Countries
China
Contacts
CONTACTFei Peng, Dr. PhD.
PRINCIPAL_INVESTIGATORYi Yang
Zhongda Hospital
Outcome results
None listed