Analyses of Newly Diagnosed HIV Infection in Hong Kong

Combined Epidemiologic and Molecular Network Analyses of Newly Diagnosed HIV Infection in Hong Kong

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07725042

Enrollment

720

Registered

2026-07-24

Start date

2024-08-01

Completion date

2029-10-01

Last updated

2026-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV -1 Infection

Keywords

HIV, people living with HIV, molecular analyses, community burden, epidemiology, Hong Kong

Brief summary

The goal of the project is to determine the epidemiologic status and changing patterns of HIV infection in Hong Kong. The main question it aims to answer is: \- what is the molecular pattern and burden of HIV-1 infections over the years

Detailed description

With the aim of determining the epidemiologic status and changing patterns of HIV infection in Hong Kong, a prospective cohort study is conducted with the objectives of: (a) describing the distribution of HIV-1 subtypes of newly diagnosed infection and their association with transmission routes; (b) characterising the transmission clusters of HIV infection and their dynamicity; and (c) evaluating the community burden of HIV and its changes over time. An epidemiologic cohort database would be established from newly diagnosed HIV infections reported in Hong Kong over a 4-year period. People living with HIV infections are invited to complete a self-administered questionnaire survey to capture data on their behavioural and network profiles prior to infection, supplemented by transcription of relevant clinical record data including CD4/CD8 and viral load measures. Blood sampling would be performed for supporting RNA sequencing. The main outcome measures are the prevalent and temporal changes of epidemiologic profile, molecular network patterns and population viral loads

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adult of age 18 or above, who are * people living with HIV, and * attending the service of an HIV specialist clinic in the public service in Hong Kong

Exclusion criteria

* travelers or visitors who are temporarily staying in Hong Kong * prisoners * patients with mental illnesses who are unable to make informed decision * patients whose HIV diagnosis was made outside Hong Kong and whose treatment have already started.

Design outcomes

Primary

Measure	Time frame	Description
main molecular HIV-1 subtype	from enrollment to the end of the study at 4 years	Proportion of patients infection with HIV-1 subtype B
main HIV transmission mode	from enrollment to end of study at 4 years	Proportion of patients who are men who have sex with men

Secondary

Measure	Time frame	Description
changes in HIV molecular pattern	from enrolment to end of study at 4 years	Percentage difference in the proportion of patients with HIV-1 subtype B between the last 2 years versus the first 2 years
Change in transmission mode	from enrolment to end of study at 4 years	Percentage difference in the proportion of patients who are men who have sex with men in the last 2 years versus the first 2 years

Countries

Hong Kong

Contacts

CONTACTShui Shan Lee, MD

sslee@cuhk.edu.hk+85261703177

CONTACTNgai Sze Wong, PhD

candy_wong@cuhk.edu.hk+85222528812

PRINCIPAL_INVESTIGATORShui Shan S Lee, MD

Chinese University of Hong Kong

Outcome results