Evaluation of Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials

Demineralized Dentin Matrix With and Without Injectable Platelet Rich Fibrin as Grafting Materials Around Immediate Dental Implants in the Maxillary Esthetic Zone

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07725029

Enrollment

Registered

2026-07-24

Start date

2025-06-01

Completion date

2026-07-01

Last updated

2026-07-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Extraction

Brief summary

Thirty two healthy patients will be selected from the outpatient clinic of the oral and maxillofacial surgery department, faculty of dentistry, Mansoura university, to be included in this study with non restorable teeth in the maxillary esthetic area. After atraumatic teeth extraction, immediate implant placement will be done and buccal jumping gap will be filled by demineralized dentin matrix in study group and control one by demineralized dentin matrix mixed with in injectable platelet rich fibrin.

Interventions

OTHERDemineralized dentin matrix grafting material

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix

OTHERDemineralized dentin matrix with injectable platelet rich fibrin

After atraumatic extraction, immediate implant placement will be performed and buccal jumping gap will be filled with demineralized dentin matrix mixed with injectable platelet rich fibrin

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Investigator, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Patient age ranged between 18-40 years old. * Patients seeking to replace non-restorable tooth / teeth in maxillary esthetic zone (anterior \&premolars) by using immediate implant placement. * Cooperative patients with high motivation and good oral hygiene. * Intact socket wall after tooth extraction. * Jumping gap more than 2mm. * Favorable occlusion without presence of parafunctional habits, eg; bruxism and clenching. * Sufficient inter-arch space to accommodate the future prothesis. * Patients able to comply with the required recall visits.

Exclusion criteria

* Patients with known systemic diseases, which can affect normal bone formation or blood coagulation. * Presence of signs of acute infection or pus formation. * Pregnancy. * Smoking. * Patients on bisphosphonate drug.

Design outcomes

Primary

Measure	Time frame	Description
implant stability	12 months	implant stability will be measured using Osstell mentor device

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 25, 2026