Kummell Disease
Conditions
Brief summary
This retrospective study compares the clinical and radiographic outcomes of percutaneous vertebroplasty (PVP) versus cement-augmented short-segment percutaneous pedicle screw fixation for the treatment of single-level stage II Kümmell's Disease (KD). A total of 60 patients who failed conservative treatment for at least 6 weeks and completed a minimum of 3 months of follow-up were included. The primary outcomes are Visual Analogue Scale (VAS) for low back and lower limb pain, and Cobb's angle correction and maintenance rates. Secondary outcomes include Oswestry Disability Index (ODI), vertebral anterior height maintenance rate, implant-related complications, and reoperation rate. This study aims to provide evidence for optimizing treatment strategies in stage II KD.
Interventions
None listed
Sponsors
The First Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
1. Patients with imaging findings consistent with stage II KD and corresponding clinical symptoms and signs; 2. All cases involve single-level lesions; 3. Individuals who have shown no improvement or experienced symptom progression after more than 6weeks of conservative treatment; 4. Patients with complete clinical and imaging data before and after surgery; 5. Those who were followed up for at least 3 months postoperatively.
Exclusion criteria
1. Patients with multilevel lumbar spondylolisthesis; 2. Individuals with a history of previous lumbar spine surgery; 3. Patients with spinal infection; 4. Individuals with uncontrolled hypertension; 5. Patients with uncontrolled diabetes mellitus; 6. Those with severe impairment of cardiac, pulmonary, liver, or kidney function; 7. Patients with gonadal diseases, adrenal diseases, parathyroid diseases, thyroid diseases, and pituitary disorders; 8. Individuals with a history of immunodeficiency diseases (such as HIV), cancer or malignant tumors, autoimmune diseases, severe cardiovascular or cerebrovascular diseases, or other conditions that may significantly reduce life expectancy; 9. Patients who have participated in any drug clinical trial within the last six months before screening; 10. Individuals with a clear history of mental illness or cognitive impairment who are unable to cooperate with follow-up and efficacy assessments; 11. Patients deemed unsuitable for participation in this study by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vertebral Anterior Height Maintenance Rate | Baseline (within 7 days preoperatively) and at the 3-month postoperative follow-up visit |
| Postoperative Incidence of Complications Related to Internal Fixation | From surgery through the 3-month postoperative follow-up visit |
| Preoperative Anterior Height of Intervertebral Disc | Baseline (within 7 days preoperatively) |
| Postoperative Anterior Height of Intervertebral Disc | At discharge |
| Preoperative Anterior Height of Ajacent Healthy Intervertebral Discs | Baseline (within 7 days preoperatively) |
| Postoperative Anterior Height of Adjacent Healthy Intervertebral Discs | At discharge |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative Lumbar Pain Visual Analogue Scale Score | At the 3-month postoperative follow-up visit | Visual Analogue Scale (VAS) for lumbar pain, ranging from 0 (no pain) to 10 (worst possible pain), with higher scores indicating worse outcome. |
| Preoperative Lumbar Pain Visual Analog Scale Score | Baseline (within 7 days preoperatively) | Visual Analogue Scale (VAS) for lumbar pain, ranging from 0 (no pain) to 10 (worst possible pain), with higher scores indicating worse outcome. |
| Postoperative Lower Extremity Pain Visual Analog Scale score | At the 3-month postoperative follow-up visit | Visual Analogue Scale (VAS) for lumbar pain, ranging from 0 (no pain) to 10 (worst possible pain), with higher scores indicating worse outcome. |
| Preoperative Lower Extremity Pain Visual Analog Scale Score | Baseline (within 7 days preoperatively) | Visual Analogue Scale (VAS) for lumbar pain, ranging from 0 (no pain) to 10 (worst possible pain), with higher scores indicating worse outcome. |
| Preoperative Oswestry Disability Index | Baseline (within 7 days preoperatively) | Oswestry Disability Index (ODI), ranging from 0 (no disability) to 50 (maximum disability), with higher scores indicating worse outcome. |
| Postoperative Oswestry Disability Index | At the 3-month postoperative follow-up visit. | Oswestry Disability Index (ODI), ranging from 0 (no disability) to 50 (maximum disability), with higher scores indicating worse outcome. |
| Preoperative Cobb's angle | Baseline (within 7 days preoperatively) | — |
| Postoperative Cobb's angle | At the 3-month postoperative follow-up visit | — |
| Reoperation rate | Up to 3 months after surgery | — |
Countries
China
Outcome results
None listed