Intrabony Periodontal Defects
Conditions
Keywords
intrabony defect - MINST - IPR-F
Brief summary
The purpose of this study is to evaluate change in pocket depth following using minimally invasive non surgical combined with injectable platelet concentrate .
Interventions
BIOLOGICALInjectable PRF
I-PRF will be prepared from 10 mL of autologous venous blood and injected into the cleaned defect, followed by placement of a custom-made transparent vacuum-formed stent for 15 minutes to prolong local contact
PROCEDUREMINST
Participants will receive minimally invasive non-surgical periodontal therapy (MINST) alone using P3 Woodpecker piezoelectric scaler for the selected periodontal intrabony defect
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Biostatistician
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Patients with periodontitis stage III-IV. * Presence of at least one intrabony defect with radiographic component ≥ 3mm deep and PPD≥ 6mm (not affecting a tooth with 'hopeless' prognosis). * Patients willing to sign informed consent and to be in the study until the 6-months follow-up. * Full-mouth plaque score \<30% following step 1 periodontal therapy
Exclusion criteria
* Smoker/vaper (currently or in past 5 years). * Contributory medical history (e.g. cardiovascular disease, diabetes, psychiatric conditions).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in pocket depth | 6 months | Baseline measurements will be taken at the first visit. Probing depth will be measured at six sites per tooth (mesiobuccal, midbuccal, distobuccal, mesiolingual, midlingual, distolingual) using a UNC-15 periodontal probe |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pocket closure | 6 months from baseline | Pocket depth of less than or equal 4 millimeters with no bleeding on probing at 6-month follow-up. PD will be measured from the gingival margin to the base of the pocket at six sites per tooth using a UNC-15 periodontal probe. PD reduction will be calculated by subtracting the 6-month PD from baseline PD |
| Clinical attachment gain | 6 months from baseline | CAL will be measured from the cementoenamel junction (CEJ) to the base of the pocket at the same six sites using a UNC-15 periodontal probe. CAL gain will be calculated by subtracting follow-up CAL (6 months) from baseline CAL |
| Radiographic defect reduction: | 6 months | Periapical radiographs of selected study sites will be taken at baseline and at 6 months using the parallel technique with Rinn holders. Each participating practice used the same setting and exposure time for radiographs taken at both visits to standardize positioning and minimize distortion of sequential radiographs |
| Patient reported outcomes | 6 months | To evaluate patient perceptions about the performed procedure and post-therapy period. The extent of discomfort and/or pain experienced will be evaluated using a horizontal visual analog scale (VAS) measured from scale from 1 to 10 where 1 is the lowest \& 10 is the highest. |
Countries
Egypt
Contacts
CONTACTHania Haggag
Outcome results
None listed