Pseudoexfoliation Syndrome, Cataract, Astigmatism
Conditions
Keywords
corneal biomechanics, corneal hysteresis, corneal resistence factor, cataract surgery, pseudoexfoliation syndrome, surgically induced astigmatism
Brief summary
This prospective study aims to evaluate the influence of corneal biomechanical properties on surgically induced astigmatism following standard phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome compared with patients without pseudoexfoliation. Corneal hysteresis (CH), corneal resistance factor (CRF) and corneal astigmatism will be measured before surgery and at postoperative follow-up visits. The relationship between changes in corneal biomechanics and surgically induced astigmatism will be analyzed.
Detailed description
Pseudoexfoliation syndrome is associated with structural alterations of the anterior segment and may affect the biomechanical behavior of the cornea. Corneal hysteresis (CH) and corneal resistance factor (CRF), measured using the Ocular Response Analyzer, are indicators of corneal biomechanical properties and may influence the corneal response to cataract surgery and magnitude of surgically induced astigmatism. This prospective, single-center observational study will include approximately 70 patients undergoing routine phacoemulsification cataract surgery. Participants will be allocated into two groups according to the presence or absence of pseudoexfoliation syndrome. CH, CRF and corneal astigmatism will be measured preoperatively and postoperatively at scheduled follow-up visits at postoperative day 1, 7 and 30. Surgically induced astigmatism will be calculated from keratometric measurements. The primary objective of the study is to determine whether correlations exist between corneal biomechanical properties (CH and CRF) and surgically induced astigmatism in patients with pseudoexfoliation syndrome and to compare these correlations with those observed in patients without pseudoexfoliation syndrome.
Interventions
PROCEDUREphacoemulsification cataract surgery
Standard phacoemulsification cataract surgery with intraocular lens implantation performed according to routine clinical practice.
Sponsors
Kata Culina
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
50 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 50-85 years * Age-related cataract scheduled for standard phacoemulsification cataract surgery with intraocular lens implantation * Presence of pseudoexfoliation syndrome (PEX group) or absence of pseudoexfoliation syndrome (control group) * Ability to provide written informed consent * Willingness to attend all scheduled postoperative follow-up visits
Exclusion criteria
* Previous ocular surgery in the study eye * Corneal diseases or abnormalities that may affect corneal biomechanical measurements or keratometry * Glaucoma and ocular hypertension * Ocular trauma or active ocular inflammation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between corneal biomechanical properties and surgically induced astigmatism | Preoperative, postoperative day 1, postoperative day 7, and postoperative day 30. | To evaluate the correlation between corneal hysteresis (CH), corneal resistance factor (CRF), and surgically induced astigmatism (SIA) after phacoemulsification cataract surgery in patients with pseudoexfoliation syndrome and compare the findings with a control group. |
Countries
Croatia
Contacts
CONTACTKata Culina, MD, PhD
CONTACTAndela Jukic, MD, PhD
Outcome results
None listed