Brain Health
Conditions
Keywords
Tubeless anesthesia, double-lumen bronchial intubation, brain health
Brief summary
This project conducts a prospective cohort study. By using multiple questionnaire survey methods such as the Pittsburgh Sleep Quality Index (PSQI) electronic wristband, QOR15, Pain Catastrophizing Scale (PCS), European Five-Dimensional Health Scale (EQ-5D), Revised American Pain Society Patient Follow-up Questionnaire (APS-POQ-R), Mini-Mental State Examination (MMSE), as well as perioperative stress and related indicators, hypothalamic-pituitary-adrenal axis (HPA) endocrine indicators, sublingual microcirculation, electroencephalogram, etc., comprehensive assessment is made of the correlations between the two different anesthesia methods of Tubeless retention of spontaneous breathing and double-lumen bronchial intubation and postoperative sleep, chronic pain and cognitive function, to construct a perioperative brain health safety system to improve prognosis; at the same time, optimize the perioperative sedation and analgesia plan and promote the postoperative brain health recovery of patients.
Interventions
None listed
Sponsors
Guangzhou Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Patient age: 18 - 75 years old * Patients meeting the standards of the American Society of Anesthesiologists (ASA) I-III grade and the New York Heart Association (NYHA) I-II class * Body Mass Index (BMI) \< 30 kg/m2 * Intraoperative blood loss less than 300 ml * No severe cardiac or pulmonary dysfunction \[first-second forced vital capacity (FEV1%) predicted value\] \> 50%, ejection fraction (EF) \> 50% * No contraindications related to paravertebral nerve block and intercostal nerve block * Able to sign the informed consent form and possess communication, reading and writing abilities * Postoperative hospital stay of at least one day * No preoperative sleep disorders, no cognitive dysfunction (PSQI ≤ 10 points, PCS ≤ 38 points, MMSE \> 27 points)
Exclusion criteria
* Already diagnosed with a mental disorder or had a preoperative Mini-Mental State Examination (MMSE) score of less than 27 * History of opioid abuse * Patients who were admitted to the ICU after surgery * Have severe cardiovascular, respiratory diseases * Experienced critical rescue during or after the surgery * Complicated with coagulation dysfunction, severe hypoxia or hypercapnia, or liver and kidney dysfunction * Difficult airway management * Changed anesthetic agent or surgical plan * Severe lacunar cerebral infarction, ischemic stroke or other neurological diseases * Changed anesthetic agent or surgical plan during the surgery;
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of cognitive function biomarkers in the serum samples of 400 patients | Before the start of the surgery (T1), at the end of the surgery (T2), and on the first day after the surgery (T3) | At time points T1, T2, and T3, 5 ml of peripheral venous blood was collected to test the biological indicators of postoperative cognitive function. |
| Concentrations of HPA axis-related indicators in the serum samples of 400 patients | Before the start of the surgery (T1), at the end of the surgery (T2) | At the TI-T2 time point, 5 ml of peripheral venous blood was collected for the detection of HPA axis-related indicators. |
| The concentrations of laboratory test indicators in the serum samples of 400 patients | Before the start of the surgery (T1), and on the first day after the surgery (T3) | Record the laboratory test indicators at time points T1 and T3 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anesthesia Record Form | at the end of the surgery (T2) | Record the vital signs at the T2 time point |
| Case information system collection | Before the start of the surgery (T1), and on the first day after the surgery (T3) | Record the pulmonary function, chest X-ray or chest CT at time points T1 and T3 |
| Postoperative follow-up records | through study completion, an average of 1 year | Record the time of chest tube removal after surgery |
Countries
China
Contacts
CONTACTLan Lan, PHD
CONTACTFengfa Yang, BS
STUDY_DIRECTORLan Lan, PHD
The First Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed