Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery

Early Postoperative L-arginine and Acute Kidney Injury After Cardiac Surgery: a Target Trial Emulation

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07718373

Enrollment

5000

Registered

2026-07-22

Start date

2026-07-20

Completion date

2026-08-20

Last updated

2026-08-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Kidney Injury

Brief summary

Acute kidney injury (AKI) is common after cardiac surgery, yet effective protective strategies remain limited. L-arginine is the substrate for endogenous nitric oxide (NO) synthesis and may improve renal perfusion and endothelial function. investigators emulated a target trial to evaluate whether early perioperative L-arginine was associated with a lower risk of AKI after cardiac surgery.

Interventions

DRUGL-arginine

Initiation of L-arginine within 3 postoperative days

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

·adults admitted to the ICU after CPB-assisted cardiac surgery

Exclusion criteria

* congenital heart disease, * surgery requiring deep hypothermic circulatory arrest, * a preoperative baseline estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m², * AKI already present prior to ICU admission

Design outcomes

Primary

Measure	Time frame	Description
Acute kidney injury	within 7 postoperative days	defined by KDIGO criteria

Secondary

Measure	Time frame	Description
7-day mortality.	7 day	7-day mortality.

Contacts

CONTACTZefei Zhang

zzfanita7@163.com18811797795

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 11, 2026