MyocarditIRM-Génétique - Genetic Sub-study of the French Cohort of Acute Myocarditis Cases Diagnosed by MRI

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07717073

Acronym

MyocarditIRM-G

Enrollment

602

Registered

2026-07-21

Start date

2025-07-15

Completion date

2027-01-01

Last updated

2026-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Myocarditis

Keywords

acute myocarditis, pathogenic genetic variants, dilated cardiomyopathies, cardiomyopathies, arrhythmogenic

Brief summary

The aim of this retrospective, non-interventional study is to assess the prevalence and describe the genetic variants found in a cohort of patients with acute myocarditis confirmed by MRI. This is a study linked to the MyocarditIRM cohort, designed to collect genetic test results obtained as part of routine clinical care.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient enrolled in MyocarditIRM * Patient who has undergone genetic testing

Exclusion criteria

* Patient who has objected to the reuse of their data

Design outcomes

Primary

Measure	Time frame
Prevalence and characterization of genetic variants (genes involved and ACMG classification) in patients with MRI-confirmed acute myocarditis.	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)

Secondary

Measure	Time frame	Description
All-cause mortality	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)	All-cause mortality during follow-up
Cardiovascular mortality	From index hospitalization for acute myocarditis up to 10 years of follow-up (including SNDS linkage when available)	Cardiovascular mortality during follow-up
Major adverse cardiovascular events	During index hospitalization and up to 10 years of follow-up (via SNDS linkage and medical records)	Occurrence of major adverse cardiovascular events, including heart failure requiring hospitalization, newly diagnosed dilated cardiomyopathy not present prior to the myocarditis episode, ventricular arrhythmias, high-degree atrioventricular block, implantation of an implantable cardioverter-defibrillator (ICD), pacemaker, wearable cardioverter-defibrillator (life vest), or implantable loop recorder, recurrent myocarditis, and heart transplantation.
Cardiac MRI sequelae	During follow-up imaging performed as part of routine clinical care, up to 10 years after index myocarditis episode	Presence of myocardial sequelae on cardiac magnetic resonance imaging (MRI) during follow-up in patients who underwent follow-up imaging as part of routine clinical care

Countries

France

Outcome results