Lower Urinary Track Symptoms, Overactive Bladder, SGLT2 Inhibitors
Conditions
Brief summary
This prospective observational study aims to evaluate the effects of sodium-glucose cotransporter 2 (SGLT-2) inhibitors on lower urinary tract symptoms (LUTS) in patients with type 2 diabetes mellitus. Patients who are newly initiated on SGLT-2 inhibitor therapy as part of routine clinical care will be evaluated at baseline and after one month using a 3-day bladder diary and the Overactive Bladder Questionnaire (OAB-v8). Changes in storage symptoms, including urinary frequency, urgency, nocturia, and urinary incontinence, will be assessed to better characterize the impact of SGLT-2 inhibitor therapy on LUTS.
Interventions
OTHERNo Intervention: Observational Cohort
No Intervention: Observational Cohort
Sponsors
Marmara University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults (≥18 years of age) * Patients with type 2 diabetes mellitus newly initiated on oral SGLT-2 inhibitor therapy
Exclusion criteria
* Age \<18 years * Patients with insulin-dependent diabetes mellitus (IDDM) * Patients with diabetes-related complications (e.g., diabetic nephropathy, retinopathy, or vasculopathy) * Patients receiving anticholinergic or α-blocker therapy for lower urinary tract symptoms (LUTS) * History of urinary incontinence surgery (including any surgical procedure involving the urethral sphincter, bladder neck, pelvic floor, or pelvic nerves) * Patients with urinary tract infection (UTI)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lower Urinary Tract Symptoms | one month |
Countries
Turkey (Türkiye)
Outcome results
None listed