Endothelial Function, Preeclampsia
Conditions
Brief summary
Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop these conditions is not known. It may be because their blood vessels were damaged during pregnancy. Changes in blood vessel health can predict heart disease. These changes have been recorded after pregnancy in women who had preeclampsia. These changes have also been recorded in women who have depression. In the previous phase of this award, we found that women who had preeclampsia in pregnancy had changes in blood vessel health after pregnancy. We also found that if these women were taking a medicine to treat depression, their blood vessel health was normal. This could mean that treatment for depression can also increase blood vessel health in women who had preeclampsia. In this project we will study how changes in blood vessel health are related to preeclampsia and depression in women who have had both. We will also study how medicine to treat depression can improve blood vessel health after preeclampsia. We will do this by measuring how blood vessels work in women who have had preeclampsia compared to women who did not, and in women who have depression and women who do not. This will tell us more about why risk for depression and heart disease is higher in women who have had preeclampsia. It will also help us understand if medicine for depression can reduce cardiovascular disease risk after preeclampsia.
Interventions
Localized delivery of paroxetine HCl to the cutaneous microvasculature via intradermal microdialysis.
Localized delivery of ascorbic acid to the cutaneous microvasculature via intradermal microdialysis.
Sponsors
Anna Stanhewicz, PhD
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Four groups of participants (women with a history of preeclampsia + current depression, women with a history of preeclampsia - current depression, women with a history of uncomplicated pregnancy + current depression, women with a history of uncomplicated pregnancy - current depression) complete single study visit with 4 localized intradermal microdialysis treatments.
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-24 years old, * 12 weeks - 5 years post pregnancy * one of the following: * history of a normal pregnancy with a current diagnosis of depression, * history of a normal pregnancy without a current diagnosis of depression, * history of a preeclamptic pregnancy with a current diagnosis of depression * history of preeclamptic pregnancy without a current diagnosis of depression.
Exclusion criteria
* history of cardiovascular, metabolic, and/or skin diseases * current or history of tobacco/nicotine/ e-cigarette use * history of gestational diabetes * current antihypertensive or cholesterol-lowering medication * currently pregnant * allergy to materials used during the experiment (e.g. latex), * known allergy to study drugs * currently using SSRI medications
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular endothelium-dependent dilation response measured by laser-Doppler flowmetry | at the study visit, an average of 4 hours | Cutaneous vascular conductance responses to local heating over a microdialysis fiber receiving treatments compared to lactated Ringer's solution (control). |
| Nitric oxide-dependent dilation response measured by laser-Doppler flowmetry | at the study visit, an average of 4 hours | Difference in cutaneous vascular conductance between local heating plateau and post-L-NAME plateau within each treated microdialysis site compared to lactated Ringer's (control). |
Countries
United States
Contacts
CONTACTAnna Reid-Stanhewicz, PHD
Outcome results
None listed