Calcium Oxalate Kidney Stones, Nephrolithiasis
Conditions
Keywords
Nephrolithiasis, Calcium Oxalate Kidney Stones, Body Mass Index
Brief summary
Nephrolithiasis is a condition characterized by the formation of crystalline stones in the urinary system. The most common component of these stones is calcium oxalate. The current study was proposed to explore the effect of different concentration of vitamin E supplementation on Calcium oxalate crystal among nephrolithiatic patients.
Detailed description
A randomized controlled trial (pre-post treatment) was conducted on 48 participants who met the inclusion criteria. The participants were selected from the OPD of Hussain Memorial Hospital in Lahore. They were divided into three groups, with each group consisting of 16 participants. The control group (T0) did not receive any treatment, while the treatment groups received different doses of Vitamin E supplementation. The first treatment group (T1) received 200mg of Vitamin E supplementation, and the second treatment group (T2) received 400mg of Vitamin E supplementation, both for a duration of 8 weeks. Data was collected at baseline and after the 8th week of the study, including blood samples for renal function tests (RFT), ultrasounds, and 24-hour urine samples for calcium and oxalate analysis.
Interventions
DRUGControl Group T0
The participants were on conventional medicines
DIETARY_SUPPLEMENTIntervention Group T1
T1 group participants were taking 200mg/day of Vitamin E supplementation once a day along with conventional medicines
DIETARY_SUPPLEMENTIntervention Group T2
T2 group participants were taking 400mg/day of Vitamin E supplementation once a day along with conventional medicines
Sponsors
University of Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 50 Years
Healthy volunteers
No
Inclusion criteria
* Both male and female. * Participants between the age of 20-50 years old. * Presence of calcium oxalate crystals in urine and kidneys * The size of the stones will range from 2 to 5 mm.
Exclusion criteria
* People having stones of Uric acid, struvite, Cystine. * People having any other medical condition (End stage renal disease, Chronic Kidney disease, Kidney failure, and dialysis) . * Subjects were excluded if they were taking any medications, which might affect vitamin E metabolism (such as Wrafrin, dalteparin sodium, enoxaparin sodium). * Pregnant and lactating females. * People having known allergies to Vitamin E supplementation (rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing). * Participants enrolled in other studies or taking other nutraceutical preparations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urine Analysis | 8 weeks | The laboratory reading of urine analysis involves the identification and microscopic examination of urine to assess the characteristics and concentration of calcium and oxalate crystals present. |
| Renal function test | 8 weeks | This involved measuring the levels of BUN (blood urea nitrogen) and creatinine in the blood. |
Countries
Pakistan
Outcome results
None listed